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验证数据展示

  • WB analysis of HeLa using 15775-1-AP (same clone as 15775-1-PBS)

    WB analysis of HeLa using 15775-1-AP (same clone as 15775-1-PBS)

    HeLa cells were subjected to SDS PAGE followed by western blot with 15775-1-AP (HTRA2 antibody) at dilution of 1:6000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15775-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 15775-1-AP (same clone as 15775-1-PBS)

    IHC staining of human kidney using 15775-1-AP (same clone as 15775-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney using 15775-1-AP (HTRA2 antibody) at dilution of 1:100 (under 10x lens). This data was developed using the same antibody clone with 15775-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 15775-1-AP (same clone as 15775-1-PBS)

    IHC staining of human kidney using 15775-1-AP (same clone as 15775-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney using 15775-1-AP (HTRA2 antibody) at dilution of 1:100 (under 40x lens). This data was developed using the same antibody clone with 15775-1-PBS in a different storage buffer formulation.

  • IP experiment of Raji using 15775-1-AP (same clone as 15775-1-PBS)

    IP experiment of Raji using 15775-1-AP (same clone as 15775-1-PBS)

    IP result of anti-HTRA2 (IP:15775-1-AP, 4ug; Detection:15775-1-AP 1:500) with Raji cells lysate 2000ug. This data was developed using the same antibody clone with 15775-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

HTRA2 Polyclonal antibody, PBS Only

HTRA2 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 15775-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat, monkey

应用

WB, IHC, IP, Indirect ELISA

别名

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

15775-1-PBS targets HTRA2 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat, monkey samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse, rat, monkey
免疫原 HTRA2 fusion protein Ag8455 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 HtrA serine peptidase 2
别名
计算分子量 49 kDa
观测分子量 36 kDa
GenBank蛋白编号BC000096
基因名称 HTRA2
Gene ID (NCBI) 27429
RRIDAB_2122835
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDO43464
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

HTRA2(High temperature requirement protein A2) is also named as OMI, PRSS25 and belongs to the peptidase S1B family. HTRA2 normally exists in the mitochondria, can cause MMP3 activation in the cytosol under a cell stress condition, which can ultimately lead to demise of dopaminergic neuronal cells(PMID: 22265821). It inhibits mitochondrial superoxide generation, stabilizes mitochondrial membrane potential, and prevents apoptosis at baseline and in response to extracellular inducers of mitochondrial stress(PMID: 18772386). This protein has 4 isoforms produced by alternative splicing.