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Host
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Conjugate
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验证数据展示

  • WB analysis of L02 using 21128-1-AP (same clone as 21128-1-PBS)

    WB analysis of L02 using 21128-1-AP (same clone as 21128-1-PBS)

    L02 cells were subjected to SDS PAGE followed by western blot with 21128-1-AP (HPSE2 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21128-1-PBS in a different storage buffer formulation.

HPSE2 Polyclonal antibody, PBS Only

HPSE2 Polyclonal Antibody for WB, Indirect ELISA
Cat No. 21128-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, Indirect ELISA

别名

heparanase 2, Hpa2, HPR2, Inactive heparanase-2

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

21128-1-PBS targets HPSE2 in WB, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human
免疫原 HPSE2 fusion protein Ag15526 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 heparanase 2
别名 heparanase 2, Hpa2, HPR2, Inactive heparanase-2
计算分子量 592 aa, 67 kDa
观测分子量 54 kDa, 66 kDa
GenBank蛋白编号BC112356
基因名称 HPSE2
Gene ID (NCBI) 60495
RRIDAB_10733344
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ8WWQ2
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

HPSE2 (heparanase 2) is a homolog of HPSE (heparanase 1). HPSE is an endo-β-glucuronidase that cleaves heparan sulfate proteoglycans (HSPGs), which are important components of the extracellular matrix and basement membranes. HPSE2, however, lacks intrinsic heparan sulfate-degrading activity. Instead, it binds to heparan sulfate with higher affinity than HPSE, thereby competing with HPSE for heparan sulfate binding and inhibiting HPSE's enzymatic activity. This competitive inhibition makes HPSE2 a crucial regulator of heparan sulfate metabolism.