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HP-β-CD

CAS号

128446-35-5

分子式

C63H112O42

主要靶点

Others

仅限科研使用

Cat No : CM01636

Print datasheet

Synonyms

羟丙基-BETA-环糊精|羟丙基-β-环糊精|Inhibitor|inhibit|(2 Hydroxypropyl) β cyclodextrin|(2Hydroxypropyl)βcyclodextrin|HP-beta-CD|HP-b-CD|Hydroxypropyl-b-cyclodextrin|Hydroxypropyl-beta-cyclodextrin|Hydroxypropyl betadex|Hydroxypropyl-β-cyclodextrin

验证数据展示

  • CAS No.: 128446-35-5

    HP-β-CD
    CAS#: 128446-35-5

产品信息

CAS号 128446-35-5
分子式 C63H112O42
主要靶点 Others
主要通路 其他
分子量 1541.5
纯度 ≥98%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 羟丙基-BETA-环糊精|羟丙基-β-环糊精|Inhibitor|inhibit|(2 Hydroxypropyl) β cyclodextrin|(2Hydroxypropyl)βcyclodextrin|HP-beta-CD|HP-b-CD|Hydroxypropyl-b-cyclodextrin|Hydroxypropyl-beta-cyclodextrin|Hydroxypropyl betadex|Hydroxypropyl-β-cyclodextrin

体内活性

腹腔注射HP-β-CD能显著提高白血病小鼠模型的存活率。将HP-β-CD系统性给药于小鼠，未观察到明显不良反应[2]。

体外活性

细胞处理(2-hydroxypropyl)-β-cyclodextrin能够激活转录因子EB（溶酶体功能和自噬的主要调节器）的激活，并增强细胞的自噬清除能力[1]。HP-β-CD处理通过G2/M细胞周期停滞和凋亡显著抑制白血病细胞生长，这是由于细胞内胆固醇的减少。72小时暴露后，HP-β-CD的IC50值在3.86–10.09 mM范围内。HP-β-CD还显示针对表达T315I BCR-ABL突变（这种突变对大多数ABL酪氨酸激酶抑制剂有抗性）的CML细胞和具有白血病干细胞特征的适应低氧的CML细胞具有抗癌效果。此外，HP-β-CD抑制人初级AML和CML细胞的集落形成能力[2]。

溶解度

H2O:50 mg/mL;DMSO:45 mg/mL (29.19 mM)

参考文献

1.Song W, et al. 2-Hydroxypropyl-β-cyclodextrin promotes transcription factor EB-mediated activation of autophagy: implications for therapy. J Biol Chem. 2014 Apr 4;289(14):10211-22.
2.Yokoo M, et al. 2-Hydroxypropyl-β-Cyclodextrin Acts as a Novel Anticancer Agent. PLoS One. 2015 Nov 4;10(11):e0141946.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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