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  • KD/KO Validated

HDAC4 Polyclonal antibody

HDAC4 Polyclonal Antibody for IHC, IP, WB, ELISA

Host / Isotype

Rabbit / IgG




IHC, IP, WB, ELISA and More (2)



Cat No : 17449-1-AP

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HA6116, HD4, HDAC A, HDAC4, HDACA, histone deacetylase 4, KIAA0288


Positive WB detected inJurkat cells, HEK-293 cells, HEK-293T cells, HeLa cells
Positive IP detected inHeLa cells
Positive IHC detected inhuman kidney tissue, human cervical cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0


Western Blot (WB)WB : 1:500-1:1000
Immunoprecipitation (IP)IP : 0.5-4.0 ug for 1.0-3.0 mg of total protein lysate
Immunohistochemistry (IHC)IHC : 1:20-1:200
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.


17449-1-AP targets HDAC4 in WB, IP, IF, IHC, CoIP, chIP, ELISA applications and shows reactivity with human samples.

Tested Applications IHC, IP, WB, ELISA Application Description
Cited ApplicationsWB, IF, IHC, CoIP, chIP
Tested Reactivity human
Cited Reactivityhuman
Immunogen HDAC4 fusion protein Ag11572 种属同源性预测
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Full Name histone deacetylase 4
Synonyms HA6116, HD4, HDAC A, HDAC4, HDACA, histone deacetylase 4, KIAA0288
Calculated Molecular Weight 972 aa, 106 kDa
Observed Molecular Weight 119-140 kDa
GenBank Accession NumberBC039904
Gene Symbol HDAC4
Gene ID (NCBI) 9759
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.


HDAC4, also named as HDACA, belongs to the histone deacetylase family. HDAC4 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC4 is Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. This antibody is a rabbit polyclonal antibody raised against an internal region of human HDAC4. The calculated molecular weight of HDAC4 is 106 kDa, but modified HDAC4 is about 140 kDa.


Product Specific Protocols
WB protocol for HDAC4 antibody 17449-1-APDownload protocol
IHC protocol for HDAC4 antibody 17449-1-APDownload protocol
IP protocol for HDAC4 antibody 17449-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols




MicroRNA Directly Enhances Mitochondrial Translation during Muscle Differentiation.

Authors - Xiaorong Zhang
  • KD Validated
humanWB, IF


Histone Deacetylase 4 promotes cholestatic liver injury in the absence of Prohibitin-1.

Authors - Lucía Barbier-Torres
  • KD Validated

Kidney Int

Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy.

Authors - Xiaojie Wang
  • KD Validated

Mol Ther Nucleic Acids

Transcriptional Factor Yin Yang 1 Promotes the Stemness of Breast Cancer Cells by Suppressing miR-873-5p Transcriptional Activity.

Authors - Qianqian Guo

J Cell Mol Med

Low levels of AMPK promote epithelial-mesenchymal transition in lung cancer primarily through HDAC4- and HDAC5-mediated metabolic reprogramming.

Authors - Shoujie Feng
  • KD Validated

J Am Heart Assoc

Phosphatidylinositol 3-Kinase-DNA Methyltransferase 1-miR-1281-Histone Deacetylase 4 Regulatory Axis Mediates Platelet-Derived Growth Factor-Induced Proliferation and Migration of Pulmonary Artery Smooth Muscle Cells.

Authors - Yanjiao Li