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Guselkumab

CAS号

1350289-85-8

分子式

N/A

主要靶点

IL Receptor

仅限科研使用

Cat No : CM11679

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Synonyms

CNTO 1959|CNTO1959|CNTO-1959|Guselkumab|IL Receptor|IL-23|ILReceptor|古塞库单抗

验证数据展示

  • CAS No.: 1350289-85-8

    Guselkumab
    CAS#: 1350289-85-8

产品信息

CAS号 1350289-85-8
分子式 N/A
主要靶点 IL Receptor
主要通路 免疫与炎症
分子量 144.8 kDa
纯度 98.97% (SEC-HPLC)， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 store at low temperature | store at -80°C | Shipping with blue ice.
别名 CNTO 1959|CNTO1959|CNTO-1959|Guselkumab|IL Receptor|IL-23|ILReceptor|古塞库单抗

靶点活性

STAT3 phosphorylation:102.1100±2.0053 nM|IL-23 (monkey):1.9 pM|IL-23 (human):3.3 pM|IL-23:0.06 nM (IC50)|IL-23:0.06 pM(kd)

体外活性

Guselkumab 在小鼠脾细胞中抑制以 IL-23 (0.5 或 1 ng/mL) 介导的 Th17 细胞因子 IL17A、IL-17F 和 IL-22 的产生，IC50 范围为 0.016-0.080 nM。同时，Guselkumab 抑制在人NKL细胞中 IL-23 (10 或 100 ng/mL) 介导的 IL-10 产生。[1] Guselkumab 结合IBI112可阻断IL-23诱导的STAT3磷酸化。Guselkumab独自阻断IL-23诱导的STAT3磷酸化，IC50值为102.1100±2.0053 nM。[2] Guselkumab 以剂量依赖性方式阻断hIL-23诱导的mIL-17产生，IC50为4.9743 ±1.2847 nM。在另一实验中，Guselkumab还能在猕猴中阻断IL-17F的产生，IC50为16.7950 nM。[2]

参考文献

1.International non-proprietary name: guselkumab Procedure No. EMEA/H/C/004271/0000par-public-assessment-report_en.pdf
2.Li L, et al. IBI112, a selective anti-IL23p19 monoclonal antibody, displays high efficacy in IL-23-induced psoriasiform dermatitis. Int Immunopharmacol. 2020;89(Pt B):107008.

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