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Golgicide A

Golgicide A 可抑制柯萨奇病毒 B3 和其他人类肠道病毒的复制。它是一种高度特异性可逆的顺式高尔基体 ADP-核糖基化因子鸟嘌呤核苷酸交换因子抑制剂。

CAS号

1139889-93-2

分子式

C17H14F2N2

主要靶点

Virus Protease|Others

仅限科研使用

Cat No : CM04226

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Synonyms

验证数据展示

  • CAS No.: 1139889-93-2

    Golgicide A
    CAS#: 1139889-93-2

产品信息

Golgicide A is a potent and rapidly reversible GBF1 inhibitor.

CAS号 1139889-93-2
分子式 C17H14F2N2
主要靶点 Virus Protease|Others
主要通路 微生物学|其他
分子量 284.3
纯度 99.93%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体外活性

Golgicide A inhibits the effect of shiga toxin on protein synthesis with an IC50 of 3.3 μM. Golgicide A causes a decrease in GBF1-mediated Arf1 activation, arrests secretion of soluble and membrane-anchored proteins and then impairs retrograde toxin transport. [1] Golgicide A decreases HCV RNA levels in FLRP1 cells and J6/JFH1 cells. In addition, Golgicide A causes redistribution of NS5A and accumulation of infectious viral particles in J6/JFH1 cells. [2]

溶解度

DMSO:14.2 mg/mL (50 mM)

参考文献

1.Sáenz JB, et al. Nat Chem Biol. 2009, 5(3), 157-16
2.Matto M, et al. J Virol. 2011, 85(2), 946-956.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2