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Golgicide A

CAS号

1139889-93-2

分子式

C17H14F2N2

主要靶点

Virus Protease|Others

仅限科研使用

Cat No : CM04226

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Synonyms

HEVs|HEV|HRV|HRVs|inhibit|Enterovirus|Golgicide A|GCA|GBF1|Virus Protease|VirusProtease|Inhibitor|Rhinovirus

验证数据展示

  • CAS No.: 1139889-93-2

    Golgicide A
    CAS#: 1139889-93-2

产品信息

CAS号 1139889-93-2
分子式 C17H14F2N2
主要靶点 Virus Protease|Others
主要通路 微生物学
分子量 284.3
纯度 99.75%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 HEVs|HEV|HRV|HRVs|inhibit|Enterovirus|Golgicide A|GCA|GBF1|Virus Protease|VirusProtease|Inhibitor|Rhinovirus

体外活性

Golgicide A通过IC50为3.3 μM的效率抑制志贺毒素对蛋白质合成的影响。Golgicide A降低GBF1介导的Arf1激活，阻断可溶性和膜锚定蛋白质的分泌，从而干扰毒素的逆行运输。[1] 此外，Golgicide A在FLRP1细胞和J6/JFH1细胞中降低HCV RNA水平，并导致NS5A的重新分布和J6/JFH1细胞中感染性病毒颗粒的积累。[2]

溶解度

DMSO:14.2 mg/mL (50 mM)

参考文献

1.Sáenz JB, et al. Nat Chem Biol. 2009, 5(3), 157-16
2.Matto M, et al. J Virol. 2011, 85(2), 946-956.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2