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Glycolic acid

CAS号

79-14-1

分子式

C2H4O3

主要靶点

Tyrosinase|Endogenous Metabolite

仅限科研使用

Cat No : CM01903

Print datasheet

Synonyms

Endogenous Metabolite|Glycolic acid|EndogenousMetabolite|inhibit|Inhibitor|Tyrosinase|乙醇酸

验证数据展示

  • CAS No.: 79-14-1

    Glycolic acid
    CAS#: 79-14-1

产品信息

CAS号 79-14-1
分子式 C2H4O3
主要靶点 Tyrosinase|Endogenous Metabolite
主要通路 代谢|蛋白酶体
分子量 76.05
纯度 97.36%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Endogenous Metabolite|Glycolic acid|EndogenousMetabolite|inhibit|Inhibitor|Tyrosinase|乙醇酸

体内活性

Glycolic acid(GA)通过减少UVB诱导的核因子κB(NF-κB)-依赖性炎症介质[白细胞介素(IL)-1β、IL-6、IL-8、环氧合酶(COX)-2、肿瘤坏死因子-α和单核细胞趋化蛋白(MCP-1)]的产生，在mRNA和蛋白质水平上实现了这一作用。GA抑制了HaCaT细胞中UVB诱导的NF-κB启动子活性，并减轻了与β-半乳糖苷酶活性相关的衰老升高，但对伤口迁移能力无影响。GA的局部应用抑制了UVB暴露小鼠皮肤中IL-1β、IL-6、IL-8、COX-2和MCP-1基因的表达。连续9天局部应用GA后，小鼠受到UVB照射，研究报告显示1-1.5%的GA对小鼠皮肤具有抗炎作用[1]。

溶解度

DMSO:50 mg/mL (657.46 mM)

动物实验

The effects of different concentrations of Glycolic acid(GA) on the inflammatory response of human keratinocytes HaCaT cells and C57BL/6J mice dorsal skin.?After GA was topically applied, HaCaT and mice skin were exposed to UVB irradiation[1].

参考文献

1.Tang S C , Liao P Y , Hung S J , et al. Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-κB signaling pathway in keratinocytes and mice skin[J]. Journal of Dermatological Science, 2017:S092318111630915X.

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