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L-Glutathione reduced

CAS号

70-18-8

分子式

C10H17N3O6S

主要靶点

Endogenous Metabolite|Ferroptosis|Reactive Oxygen Species|Glutathione reductase

仅限科研使用

Cat No : CM00285

Print datasheet

Synonyms

Ferroptosis|gamma-L-Glutamyl-L-cysteinyl-glycine|Glutathionereductase|Glutathione reductase|Glutathione|Glutathion|GSH|Endogenous Metabolite|EndogenousMetabolite|ReactiveOxygenSpecies|Reactive Oxygen Species|r-L-Glutamyl-L-cysteinyl-glycine|Isethion|L Glutathione reduced|LGlutathione reduced|L-Glutathione reduced|γ-L-Glutamyl-L-cysteinyl-glycine|Tathion|谷胱甘肽

验证数据展示

  • CAS No.: 70-18-8

    L-Glutathione reduced
    CAS#: 70-18-8

产品信息

CAS号 70-18-8
分子式 C10H17N3O6S
主要靶点 Endogenous Metabolite|Ferroptosis|Reactive Oxygen Species|Glutathione reductase
主要通路 代谢|NF-κB 信号通路|免疫与炎症|凋亡|氧化还原|代谢
分子量 307.32
纯度 99.97%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 keep away from direct sunlight | Powder: -20°C for 3 years | Shipping with blue ice.
别名 Ferroptosis|gamma-L-Glutamyl-L-cysteinyl-glycine|Glutathionereductase|Glutathione reductase|Glutathione|Glutathion|GSH|Endogenous Metabolite|EndogenousMetabolite|ReactiveOxygenSpecies|Reactive Oxygen Species|r-L-Glutamyl-L-cysteinyl-glycine|Isethion|L Glutathione reduced|LGlutathione reduced|L-Glutathione reduced|γ-L-Glutamyl-L-cysteinyl-glycine|Tathion|谷胱甘肽

体内活性

方法：为研究体内活性，将 L-Glutathione reduced (100 mg/kg) 口服给药给小鼠，并在 30、45 和 60 min 时在血浆中以及在 1 h 后在肝、肾、心脏、肺、脑、小肠和皮肤中测量 GSH 的浓度。 结果：口服 L-Glutathione reduced 给药 30 min 内，血浆中的 GSH 浓度从 30 μM 增加到 75 μM，这与 GSH 从肠腔到血浆的快速流动一致。在这些 GSH 充足的条件下，在相同的时间过程中，除肺外，大多数组织中的 GSH 浓度没有超过对照值。[2]

体外活性

方法：NSCs 细胞用 L-Glutathione reduced (0.5 mM) 和 sevoflurane (3%) 处理 24 h，使用 TUNEL 染色检测细胞凋亡。 结果：补充减少的 L-Glutathione reduced 降低了 sevoflurane 对 NSCs 凋亡的影响。[1]

溶解度

H2O:153.7 mg/mL (500 mM);DMSO:Insoluble

参考文献

1.Fan P, et al. Metformin attenuates sevoflurane-induced neurogenesis damage and cognitive impairment: involvement of the Nrf2/G6PD pathway. Metab Brain Dis. 2023 Aug;38(6):2037-2053.
2.Aw TY, et al. Oral glutathione increases tissue glutathione in vivo. Chem Biol Interact. 1991;80(1):89-97.

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