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Genipin

Genipin ((+)-Genipin) 是衍生自黄栀果实的天然交联剂，可抑制细胞中的 UCP2 (解偶联蛋白 2)。它有蛋白质调节、抗肿瘤、抗炎症、免疫抑制、抗血栓形成和对海马神经元保护的多种生物活性，可研究 2 型糖尿病。

CAS号

6902-77-8

分子式

C11H14O5

主要靶点

Autophagy|Others

仅限科研使用

Cat No : CM00280

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Synonyms

(+)-Genipin|京尼平

验证数据展示

  • CAS No.: 6902-77-8

    Genipin
    CAS#: 6902-77-8

产品信息

Genipin, an active aglycone derived from an iridoid glycoside called geniposide, is found in the fruit of Gardenia jasminoides Ellis.

CAS号 6902-77-8
分子式 C11H14O5
主要靶点 Autophagy|Others
主要通路 其他|自噬
分子量 226.23
纯度 99.74%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 (+)-Genipin|京尼平

体外活性

Genipin stimulats glucose uptake in a time- and dose-dependent manner. The maximal effect is achieved at 2?h with a concentration of 10?μM. In myotubes, genipin promotes glucose transporter 4 (GLUT4) translocation to the cell surface, which increases the phosphorylation of insulin receptor substrate-1 (IRS-1), AKT, and GSK3β. Meanwhile, genipin increases ATP levels, closed KATP channels, and then increases the concentration of calcium in the cytoplasm in C2C12 myotubes. Genipin-stimulated glucose uptake could be blocked by both the PI3-K inhibitor wortmannin and calcium chelator EGTA. Moreover, genipin increases the level of reactive oxygen species and ATP in C2C12 myotubes[1]. Genipin increases mitochondrial membrane potential, which then increases ATP levels and closes KATP channels, thereby stimulating insulin secretion in pancreatic β-cells. Genipin activates glucose-excited POMC neurons[2]. Cytochrome c content increases significantly in the cytosol of genipin-treated FaO cells. Activation of caspase-3 and caspase-7 is ultimately responsible for genipin-induced apoptotic process in hepatoma cells. ROS level notably increases in Hep3B cells treated with 200 μM genipin[3].

溶解度

Ethanol:45 mg/mL (198.91 mM),H2O:1 mg/mL (4.42 mM),DMSO:45 mg/mL (198.91 mM)

参考文献

1.Ma C, et al. Genipin stimulates glucose transport in C2C12 myotubes via IRS-1 and calcium- dependent mechanism. J Endocrinol. 2012 Dec 20.
2.Parton LE, et al. Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature. 2007 Sep 13;449(7159):228-32.
3.Kim BC, et al. Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway. Biochem Pharmacol. 2005 Nov 1;70(9):1398-407.

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