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GeA-69

CAS号

2143475-98-1

分子式

C20H16N2O

主要靶点

PARP

仅限科研使用

Cat No : CM05750

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Synonyms

cytotoxicity|DNA damage repair mechanism|HEK293|HeLa|GeA 69|GeA69|GeA-69|cell permeable|U-2 OS|poly ADP ribose polymerase|PARP|PARP14|inhibit|Inhibitor|intact cell

验证数据展示

  • CAS No.: 2143475-98-1

    GeA-69
    CAS#: 2143475-98-1

产品信息

CAS号 2143475-98-1
分子式 C20H16N2O
主要靶点 PARP
主要通路 表观遗传|DNA 损伤和修复
分子量 300.35
纯度 99.75%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 cytotoxicity|DNA damage repair mechanism|HEK293|HeLa|GeA 69|GeA69|GeA-69|cell permeable|U-2 OS|poly ADP ribose polymerase|PARP|PARP14|inhibit|Inhibitor|intact cell

靶点活性

PARP14:0.86 μM (Kd, in ITC assays)

体外活性

The macrodomain recruitment was significantly decreased in cells pre-treated with 50 μM GeA-69 and completely prevented in cells exposed to 250 μM GeA-69.

溶解度

DMSO:120 mg/mL (399.53 mM)

参考文献

1.Schuller M, et al. Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14. ACS Chem Biol. 2017 Nov 17;12(11):2866-2874.

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