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Ganitumab

Ganitumab (AMG 479) 是一种高效的1型胰岛素样生长因子受体 (IGF1R) 单克隆抗体。Ganitumab 在低浓度下识别与 IGF1R 结合，KD 值为0.22 nM，Ganitumab 对小鼠 IGF1R 与 IGF1 和 IGF2 的相互作用有抑制作用。Ganitumab 可用于研究癌症。

CAS号

905703-97-1

分子式

主要靶点

IGF-1R

仅限科研使用

Cat No : CM20658

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Synonyms

AMG 479

验证数据展示

  • CAS No.: 905703-97-1

    Ganitumab
    CAS#: 905703-97-1

产品信息

Ganitumab (AMG 479) is a highly potent monoclonal antibody to type 1 insulin-like growth factor receptor (IGF1R). Ganitumab is recognized to bind to IGF1R at low concentration with KD value of 0.22 nM. Ganitumab can inhibit the interaction of IGF1R with IGF1 and IGF2 in mice. Ganitumab can be used to study cancer.

CAS号 905703-97-1
分子式
主要靶点 IGF-1R
主要通路 蛋白酪氨酸激酶
分子量
纯度 ， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件
别名 AMG 479

体内活性

In naive and tumor-bearing mice, ganitumab (AMG 479; 1 mg/dose; i.p.) inhibited IGF1-induced activation of mIGF1R in mouse lung[1]. In female thymusless nude mice, ganitumab (300 μg/dose; i.p.) reduced peripheral blood neutrophils[1]. In male athymic nude mice, ganitumab (300 μg/dose; i.p.) resulted in impaired glucose tolerance and increased serum mGH, mIGF1, and mIGFBP3[1].

体外活性

Ganitumab (AMG 479; 0.032-500 nM; 10 minutes; cT26 cells) binds to mIGF1R and inhibits the activation of mIGF1R mediated by IGF1 and IGF2[1].

参考文献

1.Moody G, et, al. IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice. J Endocrinol. 2014 Mar 17;221(1):145-55.

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