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GW9508

CAS号

885101-89-3

分子式

C22H21NO3

主要靶点

Potassium Channel|GPR

仅限科研使用

Cat No : CM04296

Print datasheet

Synonyms

KATP|KcsA|Inhibitor|insulin|inhibit|Potassium Channel|PotassiumChannel|TNF-α|CCL5|anti-inflammatory|anti-atherosclerotic|IFN-γ|GW9508|GW-9508|Free Fatty Acid Receptor|GPR120|GPR40|glucose-sensitive|GPR40(FFA1)|GW 9508|FFAR|FFA1|CXCL10

验证数据展示

  • CAS No.: 885101-89-3

    GW9508
    CAS#: 885101-89-3

产品信息

CAS号 885101-89-3
分子式 C22H21NO3
主要靶点 Potassium Channel|GPR
主要通路 G 蛋白偶联受体|内分泌与激素|离子通道
分子量 347.41
纯度 99.19%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 KATP|KcsA|Inhibitor|insulin|inhibit|Potassium Channel|PotassiumChannel|TNF-α|CCL5|anti-inflammatory|anti-atherosclerotic|IFN-γ|GW9508|GW-9508|Free Fatty Acid Receptor|GPR120|GPR40|glucose-sensitive|GPR40(FFA1)|GW 9508|FFAR|FFA1|CXCL10

靶点活性

GPR120:5.46(pEC50)|FFA1/GPR40:7.32(pEC50)

体内活性

在MIN6细胞中,GW9508以剂量依赖的方式刺激胰岛素的分泌,同时还能增强KCl介导的胰岛素分泌增加。在大鼠β-细胞中,GW9508诱导超极化和KATP通道开放。在HaCaT细胞中,GW9508抑制TNF-α和IFN-γ诱导的IL-11,IL-24,和IL-33表达。在正常人类表皮角质形成细胞中,GW9508抑制CCL5和CXCL10产生。

溶解度

DMSO:150 mg/mL (431.77 mM);Ethanol:34.7 mg/mL (100 mM)

参考文献

1.Briscoe CP, et al. Br J Pharmacol, 2006, 148(5), 619-628.
2.Zhao YF, et al. J Endocrinol, 2008, 198(3), 533-540.
3.Fujita T, et al. J Invest Dermatol, 2011, 131(8), 1660-1667.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2