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GW604714X

CAS号

853953-65-8

分子式

C21H18FN5O5S

主要靶点

Mitochondrial Metabolism

仅限科研使用

Cat No : CM05203

Print datasheet

Synonyms

Inhibitor|MCT1|mitochondrial respiration|MitochondrialMetabolism|Mitochondrial Metabolism|MPC|Parkinson's Disease|pyruvate|GW604714X|GW-604714X|inhibit|2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-|Alzheimer's Disease

验证数据展示

  • CAS No.: 853953-65-8

    GW604714X
    CAS#: 853953-65-8

产品信息

CAS号 853953-65-8
分子式 C21H18FN5O5S
主要靶点 Mitochondrial Metabolism
主要通路 代谢
分子量 471.46
纯度 98.05%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Inhibitor|MCT1|mitochondrial respiration|MitochondrialMetabolism|Mitochondrial Metabolism|MPC|Parkinson's Disease|pyruvate|GW604714X|GW-604714X|inhibit|2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-|Alzheimer's Disease

体外活性

对大鼠肝脏和酵母线粒体进行丙酮酸运输的直接测量证实，这些试剂抑制线粒体丙酮酸载体（MPC）的活性，其K(i)值小于0.1μM。通过心脏线粒体对丙酮酸依赖性呼吸的抑制剂滴定，得出抑制剂结合位点的浓度（pmol每mg蛋白）及其K(i)(nM)分别为56.0和0.057 nM，对于更疏水的GW604714X而言。GW604714X抑制了质膜单羧酸转运体MCT1的L-乳酸运输，但其所需浓度比MPC高出四个数量级以上。

溶解度

DMF:5 mg/mL (10.61 mM);DMSO:4 mg/mL (8.48 mM)

参考文献

1.Hildyard J , Mml C , Dukes I D , et al. Identification and characterisation of a new class of highly specific and potent inhibitors of the mitochondrial pyruvate carrier[J]. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2005, 1707(2-3):221-230.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2