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GSK481

CAS号

1622849-58-4

分子式

C21H19N3O4

主要靶点

RIP kinase

仅限科研使用

Cat No : CM06682

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Synonyms

GSK481|GSK'481|GSK-481|GSK 481|inhibit|Inhibitor|RIP kinase|RIPkinase|RIP1|RIPK|Receptor-interacting protein kinases

验证数据展示

  • CAS No.: 1622849-58-4

    GSK481
    CAS#: 1622849-58-4

产品信息

CAS号 1622849-58-4
分子式 C21H19N3O4
主要靶点 RIP kinase
主要通路 凋亡|NF-κB 信号通路
分子量 377.39
纯度 99.71%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 GSK481|GSK'481|GSK-481|GSK 481|inhibit|Inhibitor|RIP kinase|RIPkinase|RIP1|RIPK|Receptor-interacting protein kinases

靶点活性

RIP1 Ser166 phosphorylation (WT, human):2.8 nM (IC50)|RIP1:1.3 nM (IC50)

体外活性

GSK481能够抑制在HEK293T细胞中过表达的人类与小鼠质粒中的RIP1 WT S166磷酸化。GSK481对人类和猕猴RIP1的RIP1 FP活性大致相当，但对非灵长类RIP[1]的活性则低了100倍以上。

溶解度

H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:70 mg/mL (185.5 mM)

参考文献

1.Harris PA, et al. J Med Chem. 2016, 59(5):2163-2178.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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