验证数据展示
产品信息
25941-1-PBS targets GPA33 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.
经测试应用 | WB, Indirect ELISA Application Description |
经测试反应性 | human, mouse |
免疫原 | GPA33 fusion protein Ag12655 种属同源性预测 |
宿主/亚型 | Rabbit / IgG |
抗体类别 | Polyclonal |
产品类型 | Antibody |
全称 | glycoprotein A33 (transmembrane) |
别名 | |
计算分子量 | 319 aa, 36 kDa |
观测分子量 | 50 kDa |
GenBank蛋白编号 | BC074830 |
基因名称 | GPA33 |
Gene ID (NCBI) | 10223 |
偶联类型 | Unconjugated |
形式 | Liquid |
纯化方式 | Protein A purification |
UNIPROT ID | Q99795 |
储存缓冲液 | PBS only, pH 7.3. |
储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Glycoprotein A33 (GPA33) is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily (PMID: 9862345; 9012807). It contains an extracellular region of 213 amino acids, a transmembrane domain, and a highly polar intracellular tail containing four consecutive cysteine residues (PMID: 9012807). GPA33 is specifically expressed on the basolateral surfaces of intestinal epithelial cells of all lineages and is found in 95% of primary and metastatic colorectal cancers (PMID: 10960348; 10950144; 21541536). GPA33 may have a role in cell adhesion and has been implicated in immune dysregulation (PMID: 9012807; 33728639).