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GLPG2938

GLPG2938 (1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea) 是一种选择性 S1P2拮抗剂，可用于特发性肺纤维化的研究。

CAS号

2130996-00-6

分子式

C20H19F6N7O2

主要靶点

LPL Receptor|S1P Receptor

仅限科研使用

Cat No : CM04979

Print datasheet

Synonyms

1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea

验证数据展示

  • CAS No.: 2130996-00-6

    GLPG2938
    CAS#: 2130996-00-6

产品信息

GLPG2938 is a potent and selective antagonist of S1P2.

CAS号 2130996-00-6
分子式 C20H19F6N7O2
主要靶点 LPL Receptor|S1P Receptor
主要通路 G蛋白偶联受体
分子量 503.4
纯度 98.10%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea

体内活性

In all species ,GLPG2938 shows good pharmacokinetics, with long half-life,low clearance,and good bioavailability.

体外活性

GLPG2938 significantly prevents the S1P-mediated contraction at all tested concentrations[1].

溶解度

DMSO:60 mg/ml (119.19 mM)

参考文献

1.Discovery of the S1P2 Antagonist GLPG2938 (1-[2-Ethoxy-6-(trifluoromethyl)-4-pyridyl]-3-[[5-methyl-6-[1-methyl-3-(trifluoromethyl)pyrazol-4-yl]pyridazin-3-yl]methyl]urea), a Preclinical Candidate for the Treatment of Idiopathic Pulmonary Fibrosis[J]. Journal of Medicinal Chemistry, 2021, 64(9):6037-6058.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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