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GET73

GET73 (Gamma hydroxybutyric acid analogue) 是天然神经递质 γ-羟基丁酸的类似物。它对谷氨酸在海马的传递有显著的影响。它具有抗酒精和抗焦虑的作用。

CAS号

202402-01-5

分子式

C13H16F3NO2

主要靶点

GluR

仅限科研使用

Cat No : CM05087

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Synonyms

GET 73|Gamma hydroxybutyric acid analogue

验证数据展示

  • CAS No.: 202402-01-5

    GET73
    CAS#: 202402-01-5

产品信息

GET73 is an negative allosteric modulator of mGluR5. GET73 is a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties.

CAS号 202402-01-5
分子式 C13H16F3NO2
主要靶点 GluR
主要通路 神经科学
分子量 275.27
纯度 99.54%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 GET 73|Gamma hydroxybutyric acid analogue

体内活性

GET73 exerts an anxiolytic effect in Sprague-Dawley rats exposed to the elevated plus maze (EPM) test.

体外活性

GET73 (1 μM, 10 μM; 1 hour) 1 hour before and during chronic ethanol exposure prevents ethanol-induced a reduction of cell viability, an alteration of cytoskeleton, an increase of reactive oxygen species production?and a decrease in extracellular glutamate levels.

溶解度

DMSO:97 mg/mL (352.38 mM),Sonification is recommended.

参考文献

1.Tomasini MC, et al. GET73 Prevents Ethanol-Induced Neurotoxicity in Primary Cultures of Rat Hippocampal Neurons. Alcohol Alcohol. 2016 Mar;51(2):128-35.
2.Ferraro L, et al. GET73 modulates rat hippocampal glutamate transmission: evidence for a functional interaction with mGluR5. Pharmacol Rep. 2011;63(6):1359-71.
3.Loche A, et al. Anti-Alcohol and Anxiolytic Properties of a New Chemical Entity, GET73. Front Psychiatry. 2012 Feb 14;3:8.

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