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Fmoc-Val-Cit-PAB

Fmoc-Val-Cit-PAB 是一种可降解的抗体-药物偶联的连接剂。

CAS号

159858-22-7

分子式

C33H39N5O6

主要靶点

Others

仅限科研使用

Cat No : CM00860

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Synonyms

验证数据展示

  • CAS No.: 159858-22-7

    Fmoc-Val-Cit-PAB
    CAS#: 159858-22-7

产品信息

Fmoc-Val-Cit-PAB is a linker for antibody-drug-conjugation (ADC).

CAS号 159858-22-7
分子式 C33H39N5O6
主要靶点 Others
主要通路 其他
分子量 601.69
纯度 97.18%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

溶解度

DMSO:123.75 mg/mL (205.67 mM)

参考文献

1.Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc42020050k. Epub 2013 May 3. Sano K, Nakajima T, Miyazaki K, Ohuchi Y, Ikegami T, Choyke PL, Kobayashi H. Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes. Bioconjug Chem. 2013 May 15;24(5):811-6. doi: 10.1021/bc42020050k. Epub 2013 May 3.
2.Augusto MT, Hollmann A, Porotto M, Moscona A, Santos NC. Antiviral Lipopeptide-Cell Membrane Interaction Is Influenced by PEG Linker Length. Molecules. 2017 Jul 15;22(7).
3.Tuma R, Russell M, Rosendahl M, Thomas GJ Jr. Solution conformation of the extracellular domain of the human tumor necrosis factor receptor probed by Raman and UV-resonance Raman spectroscopy: structural effects of an engineered PEG linker. Biochemistry. 1995 Nov 21;34(46):15150-6.
4.Kanazaki K, Sano K, Makino A, Yamauchi F, Takahashi A, Homma T, Ono M, Saji H. Feasibility of poly(ethylene glycol) derivatives as diagnostic drug carriers for tumor imaging. J Control Release. 2016 Mar 28;226:115-23. doi:10.12016/j.jconrel.2016.02.2017. Epub 2016 Feb 8.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2