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Fenbufen

Fenbufen (Lederfen) 是一种非甾体抗炎药，主要用于治疗骨关节炎、强直性脊柱炎和肌腱炎的炎症。它还可用于缓解背痛、扭伤和骨折，具有 caspases 的抑制活性。它对 COX-1和 COX-2具有抑制活性，其 IC50分别为 3.9 μM 和 8.1 μM。

CAS号

36330-85-5

分子式

C16H14O3

主要靶点

COX|Caspase|ATPase

仅限科研使用

Cat No : CM00258

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Synonyms

芬布芬|CL-82204|Lederfen

验证数据展示

  • CAS No.: 36330-85-5

    Fenbufen
    CAS#: 36330-85-5

产品信息

Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures. Fenbufen is available as a capsule or tablet sold with the brand names Cepal, Cinopal, Cybufen, Lederfen, and Reugast. Fenbufen acts by preventing cyclooxygenase from producing prostaglandins which can cause inflammation.

CAS号 36330-85-5
分子式 C16H14O3
主要靶点 COX|Caspase|ATPase
主要通路 凋亡|免疫与炎症|蛋白酶体|神经科学|离子通道
分子量 254.28
纯度 98.35%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 芬布芬|CL-82204|Lederfen

靶点活性

ATP systhesis:0.88 μM(Ki)

体内活性

Fenbufen and its metabolites could be involved in mitochondrial toxicity through inhibition of ATP synthesis[1]. Fenbufen inhibited prostaglandin release by 80% and reduced rates of protein synthesis in normal muscle and in muscle undergoing hypertrophy in response to tenotomy of a synergist[3].

溶解度

H2O:<1 mg/mL,DMSO:47 mg/mL (184.8 mM),Ethanol:47 mg/mL (184.8 mM)

参考文献

1.Syed M, et al. Toxicol In Vitro. 2016, 31:23-29.
2.Naora K, et al. J Antimicrob Chemother. 1992, 30(5):673-683.
3.Palmer RM, et al. Br J Pharmacol. 1990, 101(4):835-838.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2