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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

验证数据展示

  • WB analysis using 19832-1-AP (same clone as 19832-1-PBS)

    WB analysis using 19832-1-AP (same clone as 19832-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 19832-1-AP (FUNDC2 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 19832-1-PBS in a different storage buffer formulation.

  • IHC staining of human stomach cancer using 19832-1-AP (same clone as 19832-1-PBS)

    IHC staining of human stomach cancer using 19832-1-AP (same clone as 19832-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 19832-1-AP (FUNDC2 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 19832-1-PBS in a different storage buffer formulation.

  • IHC staining of human stomach cancer using 19832-1-AP (same clone as 19832-1-PBS)

    IHC staining of human stomach cancer using 19832-1-AP (same clone as 19832-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using 19832-1-AP (FUNDC2 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 19832-1-PBS in a different storage buffer formulation.

FUNDC2 Polyclonal antibody, PBS Only

FUNDC2 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 19832-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

HCC 3, HCBP6, FUN14 domain-containing protein 2, FUN14 domain containing 2, DC44

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

19832-1-PBS targets FUNDC2 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原 FUNDC2 fusion protein Ag13800 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 FUN14 domain containing 2
别名 HCC 3, HCBP6, FUN14 domain-containing protein 2, FUN14 domain containing 2, DC44
计算分子量 189 aa, 21 kDa
观测分子量21 kDa
GenBank蛋白编号BC000255
基因名称 FUNDC2
Gene ID (NCBI) 65991
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9BWH2
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

FUNDC2, or FUN14 domain-containing protein 2, is a mitochondrial outer membrane protein that plays a significant role in various cellular processes, including the regulation of cell survival, apoptosis, and metabolism. It has been implicated in the progression of several types of cancer, particularly in triple-negative breast cancer (TNBC) and liver cancer. In the context of cancer, FUNDC2 has been shown to promote tumorigenesis. It is associated with poor prognosis in hepatocellular carcinoma (HCC) and is involved in mitochondrial fragmentation by inhibiting MFN1-mediated mitochondrial fusion, which can lead to changes in cellular metabolism and energy levels. FUNDC2 also plays a role in platelet function and survival. It binds directly to phosphatidylinositol-3,4,5-trisphosphate (PIP3), which is a key lipid second messenger in cell signaling, and this interaction is crucial for the recruitment of PIP3 to mitochondria. FUNDC2 deficiency has been shown to decrease platelet aggregation and impair hemostasis in mice, highlighting its importance in platelet function.