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FG-2216

CAS号

223387-75-5

分子式

C12H9ClN2O4

主要靶点

HIF/HIF Prolyl-Hydroxylase

仅限科研使用

Cat No : CM04465

Print datasheet

Synonyms

erythropoietin|FG2216|FG-2216|fetal|FG 2216|hydroxylase|Hypoxia-inducible factors|HIF Prolyl-Hydroxylase|HIF ProlylHydroxylase|HIF/HIF Prolyl-Hydroxylase|HIF/HIF ProlylHydroxylase|HIF/HIFProlylHydroxylase|HIF|HIFProlylHydroxylase|HIF-PH|HIFs|hemoglobin|inhibit|IOX3|IOX-3|IOX 3|Inhibitor|PHD2|prolyl|YM 311|YM311|YM-311

验证数据展示

  • CAS No.: 223387-75-5

    FG-2216
    CAS#: 223387-75-5

产品信息

CAS号 223387-75-5
分子式 C12H9ClN2O4
主要靶点 HIF/HIF Prolyl-Hydroxylase
主要通路 表观遗传|代谢
分子量 280.66
纯度 100%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 erythropoietin|FG2216|FG-2216|fetal|FG 2216|hydroxylase|Hypoxia-inducible factors|HIF Prolyl-Hydroxylase|HIF ProlylHydroxylase|HIF/HIF Prolyl-Hydroxylase|HIF/HIF ProlylHydroxylase|HIF/HIFProlylHydroxylase|HIF|HIFProlylHydroxylase|HIF-PH|HIFs|hemoglobin|inhibit|IOX3|IOX-3|IOX 3|Inhibitor|PHD2|prolyl|YM 311|YM311|YM-311

靶点活性

PHD2:3.9 μM

体内活性

在雄性恒河猴中，FG-2216（60 mg/kg，口服）可显著且可逆地诱导Epo产生，并引起HbF表达的小幅提升。[2]

体外活性

FG-2216 展现出稳定 HIF-α 以刺激 EPO 分泌的能力。[1]

溶解度

DMSO:50 mg/mL (178.15 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

参考文献

1.Hong YR, et al. Bioorg Med Chem Lett. 2013, 23(21), 5953-5957.
2.Hsieh MM, et al. Blood. 2007, 110(6), 2140-2147.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
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C1   V1   C2   V2