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验证数据展示

  • IHC staining of human liver using 17139-1-AP (same clone as 17139-1-PBS)

    IHC staining of human liver using 17139-1-AP (same clone as 17139-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 17139-1-AP (FBXL13 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17139-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver using 17139-1-AP (same clone as 17139-1-PBS)

    IHC staining of human liver using 17139-1-AP (same clone as 17139-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 17139-1-AP (FBXL13 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 17139-1-PBS in a different storage buffer formulation.

FBXL13 Polyclonal antibody, PBS Only

FBXL13 Polyclonal Antibody for IHC, Indirect ELISA
Cat No. 17139-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

IHC, Indirect ELISA

别名

DRC6, Dynein regulatory complex subunit 6, FBL13, F-box and leucine-rich repeat protein 13, F-box/LRR-repeat protein 13

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

17139-1-PBS targets FBXL13 in IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag10903

Product name: Recombinant human FBXL13 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 358-707 aa of BC031285

Sequence: NDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEAFCKSSLILEHLDVSYCSQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQRMSSKVQQQEYNTNGPPRWFGYDREGNPVTELDNITSSKGALELTVKKSTYSSEDQAA

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 F-box and leucine-rich repeat protein 13
别名 DRC6, Dynein regulatory complex subunit 6, FBL13, F-box and leucine-rich repeat protein 13, F-box/LRR-repeat protein 13
计算分子量 707 aa, 81 kDa
GenBank蛋白编号BC031285
基因名称 FBXL13
Gene ID (NCBI) 222235
RRIDAB_2103869
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ8NEE6
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

FBXL13, a binding determinant of SCF (SKP1-CUL1-F-box)-family E3 ubiquitin ligases, is enriched at centrosomes and interacts with the centrosomal proteins Centrin-2, Centrin-3, CEP152 and CEP192. Induced FBXL13 expression downregulates centrosomal γ-tubulin and disrupts centrosomal microtubule arrays. FBXL13 is a novel regulator of microtubule nucleation activity and participate in promoting cell motility with potential tumour-promoting implications (PMID: 29348145).

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