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Evans blue

Evans blue (C.I. 23860) 是一种突触泡谷氨酸吸收的有效抑制剂，同时也是一种AMPA/kainate 受体拮抗剂。

CAS号

314-13-6

分子式

C34H24N6Na4O14S4

主要靶点

GluR

仅限科研使用

Cat No : CM05086

Print datasheet

Synonyms

C.I. 23860|Direct Blue 53|伊文思蓝

验证数据展示

  • CAS No.: 314-13-6

    Evans blue
    CAS#: 314-13-6

产品信息

Evans blue (C.I. 23860) is an azo dye, inhibits L-glutamate uptake via the membrane-bound excitatory amino acid transporter (EAAT).

CAS号 314-13-6
分子式 C34H24N6Na4O14S4
主要靶点 GluR
主要通路 神经科学
分子量 960.78
纯度 85.86%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 C.I. 23860|Direct Blue 53|伊文思蓝

靶点活性

vesicular glutamate uptake:87 nM

体内活性

Evans blue pretreatment could inhibit the mast cells degranulation and that may be the main mechanism for prevent animals from C48/80-triggered anaphylaxis and systemic inflammation[4]. Evans blue modulates the non-N-methyl-d-aspartate receptor in rat thalamic neurons, blocks the P2X-purinergic receptor in rat vas deferens, and inhibits the glutamate transporter in rat brain synaptic vesicles[6].

体外活性

Evans Blue is found to be inhibiting DNA binding of NF-κB at a low concentration of 100 μM[1]. It has proven over the years to be a dependable stain for microscopic determination of cell death[2]. Evans Blue is also a known blocker of a subset of a-amino-3-hydroxy-5-methyl-isoxazole/kainate receptors (IC50=355 nM) for the subunit combination GluR1,2[5]. Evans blue is the first known δ-subunit-specific antagonist of ENaC and activates large-conductance Ca2+-activated K+ channels in sheep bladder myocytes and cultured endothelial cells of human umbilical veins[5].

溶解度

H2O:104.1 mM,DMSO:104.1 mM

参考文献

1.Sharma RK, et al. Bioorg Med Chem Lett. 2004, 14(24):6123-7.
2.C. Jacyn Baker, et al. Plant Cell, Tissue and Organ Culture. 1994, 39(1):7-12.
3.Miller DL, et al. Ultrasound Med Biol. 2007, 33(12):1988-96.
4.Yu-Tong Chen, et al. FASEB Journal. 2016, 30(1): Supplement 723.10.
5.Roseth S, et al. Biochem Pharmacol. 1998, 56(9):1243-9.

The molarity calculator equation

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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