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Esomeprazole

Esomeprazole 是奥美拉唑(omeprazole) 的S-异构体，抑制溶酶体半胱氨酸蛋白酶legumain，防止癌症转移。它是一种质子泵抑制剂（PPI）。

CAS号

119141-88-7

分子式

C17H19N3O3S

主要靶点

Proton pump|Cysteine Protease

仅限科研使用

Cat No : CM00723

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Synonyms

验证数据展示

  • CAS No.: 119141-88-7

    Esomeprazole
    CAS#: 119141-88-7

产品信息

Esomeprazole is the S-isomer of omeprazole, inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. Esomeprazole is a proton pump inhibitors (PPI).

CAS号 119141-88-7
分子式 C17H19N3O3S
主要靶点 Proton pump|Cysteine Protease
主要通路 蛋白酶体|离子通道
分子量 345.42
纯度 98.20%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体内活性

In an orthotopic transplantation nude mouse model, Esomeprazole reduced lung metastasis of MDA-MB-231 breast cancer cells[1].

溶解度

DMSO:15 mg/mL (43.43 mM)

参考文献

1.Zhao T, et al. Esomeprazole inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. Invest New Drugs. 2021 Apr;39(2):337-347.
2.Vachhani R, et al. Esomeprazole: a proton pump inhibitor. Expert Rev Gastroenterol Hepatol. 2009 Feb;3(1):15-27.
3.Qi Q,et al. Comparative effectiveness and tolerability of esomeprazole and omeprazole in gastro-esophageal reflux disease: A systematic review and meta-analysis. Int J Clin Pharmacol Ther. 2015 Oct;53(10):803-10.
4.Jankowski JAZ, et al. Esomeprazole and aspirin in Barrett's oesophagus (AspECT): a randomised factorial trial. Lancet. 2018 Aug 4;392(10145):400-408.

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The dilution calculator equation

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