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(-)-(S)-Equol

CAS号

531-95-3

分子式

C15H14O3

主要靶点

Endogenous Metabolite|Estrogen Receptor/ERR|Estrogen/progestogen Receptor

仅限科研使用

Cat No : CM00594

Print datasheet

Synonyms

progestogen Receptor|progestogenReceptor|雌马酚|EndogenousMetabolite|ERβ|ERR|Equol|Estrogen Receptor/ERR|EstrogenReceptor|Estrogen Receptor|Endogenous Metabolite|4',7-Isoflavandiol|4',7-Dihydroxyisoflavan|(?)-Equol

验证数据展示

  • CAS No.: 531-95-3

    (-)-(S)-Equol
    CAS#: 531-95-3

产品信息

CAS号 531-95-3
分子式 C15H14O3
主要靶点 Endogenous Metabolite|Estrogen Receptor/ERR|Estrogen/progestogen Receptor
主要通路 内分泌与激素|内分泌与激素|代谢
分子量 242.27
纯度 99.61%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 progestogen Receptor|progestogenReceptor|雌马酚|EndogenousMetabolite|ERβ|ERR|Equol|Estrogen Receptor/ERR|EstrogenReceptor|Estrogen Receptor|Endogenous Metabolite|4',7-Isoflavandiol|4',7-Dihydroxyisoflavan|(?)-Equol

靶点活性

ERRβ:0.73 nM(Ki)

体外活性

Equol是由肠道微生物作用于大豆植物雌激素daidzein产生的代谢产物。该化合物对两种ER（雌激素接受器，包括ERalpha和ERbeta）具有更高的亲和力。Equol以R-equol和S-equol的对映异构体存在，其中S-equol对ERbeta具有较高的结合亲和力，Ki值为16 nM；而R-equol的结合力相对较弱，偏好与ERalpha结合，Ki值为50 nM。[1] 在抗氧化活性方面，Equol优于所有其他异黄酮。[2] Equol具有抗雌激素特性。[3] 在刺激雌激素反应方面，Equol的效力是daidzein的100倍。与daidzein相比，Equol在与3 H-雌二醇竞争结合到ER时更为有效。Equol以浓度依赖的方式促进MCF-7细胞的生长。尽管Equol表现出雌激素活性，但将MCF-7细胞同时暴露于Equol和雌二醇中，可以有效降低pS2 mRNA表达，从而导致ER mRNA表达的下调。[4]

溶解度

Ethanol:24.2 mg/mL (100 mM);DMSO:45 mg/mL (185.74 mM)

细胞实验

Each well of a 24-well plate is seeded with 1 × 105 MCF-7 cells in 1 mL of media B. Twenty-four hours after plating, equol at the indicated concentration is added. Equol is dissolved in ethanol (final concentration of ethanol in the medium is 1%). The medium is changed every 24 hours and equol is replenished with each change. Cell growth is determined on the sixth day by the sulphorhodamine colorimetric assay. After colour development, aliquots are pipetted into a 96-well microtitre plate and the absorbance is determined at 570 nm using an Elisa microplate reader.(Only for Reference)

参考文献

1.Muthyala RS, et al. Bioorg Med Chem, 2004, 12(6), 1559-1567.
2.Setchell KD, et al. J Nutr, 2002, 132(12), 3577-3584.
3.Adlercreutz H, et al. Lancet, 1982, 2(8311), 1295-1299.
4.Sathyamoorthy N, et al. Eur J Cancer, 1997, 33(14), 2384-2389.

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