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Elevenostat

CAS号

1454902-97-6

分子式

C16H17N3O4

主要靶点

HDAC

仅限科研使用

Cat No : CM04421

Print datasheet

Synonyms

Histone deacetylases|HDAC|HDAC11|inhibit|Elevenostat|multiple myeloma|Inhibitor|JB3-22

验证数据展示

  • CAS No.: 1454902-97-6

    Elevenostat
    CAS#: 1454902-97-6

产品信息

CAS号 1454902-97-6
分子式 C16H17N3O4
主要靶点 HDAC
主要通路 表观遗传|DNA 损伤和修复
分子量 315.32
纯度 96%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Histone deacetylases|HDAC|HDAC11|inhibit|Elevenostat|multiple myeloma|Inhibitor|JB3-22

靶点活性

HDAC11:0.235?μM

体内活性

Elevenostat 在活体内显示出了与多发性骨髓瘤（MM）相似的抗活性，提高了接种5TGM1 MM细胞的小鼠的存活率[1]。

体外活性

Elevenostat在MM细胞系中诱导细胞死亡[1]。

溶解度

DMSO:250 mg/mL (792.85 mM)

参考文献

1.Mostofa A, et al. Plasma cell dependence on histone/protein deacetylase 11 reveals a therapeutic target in multiple myeloma. JCI Insight. 2021;6(24):e151713. Published 2021 Dec 22.
2.Huang J, et al. Histone/protein deacetylase 11 targeting promotes Foxp3+ Treg function. Sci Rep. 2017;7(1):8626. Published 2017 Aug 17.

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