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Dolastatin 10

Dolastatin 10 (DLS 10) 是一种多肽，可以抑制微管蛋白聚合，显示除抗有丝分裂的活性。

CAS号

110417-88-4

分子式

C42H68N6O6S

主要靶点

Microtubule Associated

仅限科研使用

Cat No : CM05123

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Synonyms

NSC 376128|尾海兔素10|DLS 10

验证数据展示

  • CAS No.: 110417-88-4

    Dolastatin 10
    CAS#: 110417-88-4

产品信息

Dolastatin 10 is a potent antimitotic peptide that inhibits tubulin polymerization.

CAS号 110417-88-4
分子式 C42H68N6O6S
主要靶点 Microtubule Associated
主要通路 细胞骨架
分子量 785.09
纯度 ， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 NSC 376128|尾海兔素10|DLS 10

体外活性

Dolastatin 10 is a unique pentapeptide that isolated from the sea hare?Dolabella auricularia. These in vitro data are quite comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI50?values of 10?5-10?6?μg/mL (10?2-10?3?nM) against a similar minipanel of human cell lines[1]. The antibody-drug conjugate (ADC) comprises the anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10[2].

溶解度

DMSO:100 mg/mL (127.37 mM)

参考文献

1.Pitot HC, et al. Phase I trial of dolastatin-10 (NSC 376128) in patients with advanced solid tumors. Clin Cancer Res. 1999 Mar;5(3):525-31.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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