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Dihydrocurcumin

Dihydrocurcumin 是姜黄素的主要代谢物，具有减少脂肪积累和减少氧化应激反应的作用。Dihydrocurcumin 可调控SREBP-1C，PNPLA3 和 PPARα 的 mRNA 和蛋白表达水平，使pAKT 和 PI3K 的蛋白表达水平增高，通过 Nrf2 信号通路使细胞胞内 NO 和 ROS 的含量减少。

CAS号

76474-56-1

分子式

C21H22O6

主要靶点

PPAR|Fatty Acid Synthase

仅限科研使用

Cat No : CM11517

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Synonyms

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  • CAS No.: 76474-56-1

    Dihydrocurcumin
    CAS#: 76474-56-1

产品信息

Dihydrocurcumin is the main metabolite of curcumin, which can reduce fat accumulation and oxidative stress response. Dihydrocurcumin can regulate the mRNA and protein expression levels of SREBP-1C, PNPLA3 and PPARα, increase the protein expression levels of pAKT and PI3K, and reduce the intracellular NO and ROS contents through Nrf2 signaling pathway.

CAS号 76474-56-1
分子式 C21H22O6
主要靶点 PPAR|Fatty Acid Synthase
主要通路 DNA损伤和修复|代谢
分子量 370.4
纯度 97.23%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名

体外活性

Colon bacteria may mediate the transformation of curcumin, but this metabolism has not been well studied. Methods AND RESULTS: The metabolism of curcumin to Escherichia Ferguson (ATCC 35469) and two strains of Escherichia coli (ATCC 8739 and DH10B) was studied in modified colonic bacteria (mMCB) medium of porcine cecal fluid with or without medication. LC-MS analysis showed that after fermentation for 36 h, the conversion rate of curcumin was 16-37%, the conversion rate of demethoxycurcumin (DMC) was 6-16%, the conversion rate of dimethoxycurcumin (bi-DMC) was 7-15%, and the conversion rate of dimethoxycurcumin (bi-DMC) was 7-15%. The amount of curcumin degradation varies with different strains and medium. Three metabolites (dihydrocurcumin (DHC), tetrahydrocurcumin (THC) and ferulic acid (FA)) were identified in the fermentation culture of all strains. In addition, a compound of m/z [M-H](-) 470 was found and identified as curcumin-adduct (curcumin-L-cysteine) by precise mass FT-ICR-MS. Conclusion: This study provides a new scheme for the bacterial metabolism of curcumin[1].

溶解度

DMSO:22.5 mg/mL (60.7 mM),ultrasonic and warming and heat to 60°C

参考文献

1.Qingqing Yu, et al.Dihydrocurcumin ameliorates the lipid accumulation, oxidative stress and insulin resistance in oleic acid-induced L02 and HepG2 cells.Biomedicine & Pharmacotherapy Volume 103, July 2018, Pages 1327-1336
2.Azam Hassaninasab, et al.Discovery of the curcumin metabolic pathway involving a unique enzyme in an intestinal microorganism. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6615-20.
3.Suryani Tan, et al. Degradation of curcuminoids by in vitro pure culture fermentation. J Agric Food Chem. 2014 Nov 12;62(45):11005-15.
4.Pierre Kamnaing.et al.Trypanocidal diarylheptanoids from Aframomum letestuianum.J Nat Prod. 2003 Mar;66(3):364-7.

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