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Deoxyelephantopin

CAS号

29307-03-7

分子式

C19H20O6

主要靶点

NF-κB

仅限科研使用

Cat No : CM11739

Print datasheet

Synonyms

β-catenin|ROS|去氧地胆草素|MAPK|inhibit|Inhibitor|Nuclear factor-κB|Nuclear factor-kappaB|NFkB|NF-kB|NFκB|NF-κB|PI3K|Bcl-2|Caspase|anticancer|Akt|Deoxyelephantopin

验证数据展示

  • CAS No.: 29307-03-7

    Deoxyelephantopin
    CAS#: 29307-03-7

产品信息

CAS号 29307-03-7
分子式 C19H20O6
主要靶点 NF-κB
主要通路 NF-κB 信号通路
分子量 344.36
纯度 99.69%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 store at low temperature,keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 β-catenin|ROS|去氧地胆草素|MAPK|inhibit|Inhibitor|Nuclear factor-κB|Nuclear factor-kappaB|NFkB|NF-kB|NFκB|NF-κB|PI3K|Bcl-2|Caspase|anticancer|Akt|Deoxyelephantopin

体外活性

Deoxyelephantopin的影响经过评估，主要涉及CYP1A2、CYP2D6和CYP3A4编码mRNAs的表达，以及蛋白质表达和随之产生的酶活性。通过使用优化的多重qRT-PCR分析和Western blot分析，对细胞色素同工酶的mRNA和蛋白质表达进行了研究。利用优化的hCYP3A4-HepG2细胞基测定法确定了人CYP3A4蛋白质的表达，并通过P450-Glo CYP3A4测试评估了其酶活性。通过计算机模拟方法确定了Deoxyelephantopin对CYP3A4酶的分子相互作用和可能的抑制，并通过特定底物的CYP3A4抑制测试进行了验证。Deoxyelephantopin对CYP1A2和CYP2D6的mRNA和蛋白质表达没有显著效果。然而，它在转录水平对CYP3A4有微弱的诱导作用[1]。

溶解度

DMSO:100 mg/mL (290.39 mM)

参考文献

1.Evaluation of in vitro cytochrome P450 induction and inhibition activity of deoxyelephantopin, a sesquiterpene lactone from Elephantopus scaber L.Food Chem Toxicol. 2013 Oct;60:98-108.

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