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Demethylzeylasteral

Demethylzeylasteral (Demethylzeylasteral (T-96)) 是一种从雷公藤中分离出的三萜烯化合物，具有抗炎、免疫抑制和抗肿瘤活性。它通过阻断 TGF-β 信号通路，抑制三阴性乳腺癌的侵袭。它能显著减轻动脉粥样硬化。

CAS号

107316-88-1

分子式

C29H36O6

主要靶点

Apoptosis|UGT

仅限科研使用

Cat No : CM06758

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Synonyms

去甲泽拉木醛|Demethylzeylasteral (T-96)

验证数据展示

  • CAS No.: 107316-88-1

    Demethylzeylasteral
    CAS#: 107316-88-1

产品信息

Demethylzeylasteral has strong immunosuppressive activity, can be used in the fields of organ transplantation and autoimmune disorders. The risk of elevated serum concentrations of estradiol due to the inhibition of estradiol glucuronidation by Demethylzeylasteral. Demethylzeylasteral increases both activation and inactivation time constants of Ca(2+) currents, can inhibit significantly the sperm acrosome reaction initiated by progesterone.

CAS号 107316-88-1
分子式 C29H36O6
主要靶点 Apoptosis|UGT
主要通路 代谢|凋亡
分子量 480.59
纯度 99.54%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 去甲泽拉木醛|Demethylzeylasteral (T-96)

靶点活性

UGT1A6:0.6 μM(Ki)|UGT2B7:17.3 μM(Ki)

溶解度

DMSO:87 mg/mL(181 mM)

参考文献

1.Liu SL et al. Eur J Drug Metab Pharmacokinet. 2014 Jun;39(2):99-102.
2.Zhao JW, et al. Molecules. 2012 Aug 8;17(8):9469-75.
3.Xu W, et al. Int Immunopharmacol. 2009 Jul;9(7-8):1996-12001.
4.Zhao Y, et al. Demethylzeylasteral inhibits cell proliferation and induces apoptosis through suppressing MCL1 in melanoma cells. Cell Death Dis. 2017 Oct 26;8(10):e3133.
5.Experimental study of the anti-atherosclerotic effect of demethylzeylasteral. Exp Ther Med. 2017 Jun;13(6):2787-2792.
6.Yang D L, Zhang Y, He L, et al. Demethylzeylasteral (T-96) Initiates Extrinsic Apoptosis Against Prostate Cancer cells by Inducing ROS-Mediated ER Stress and Suppressing Autophagic Flux[J]. 2021
7.Yang Y, Zhao M, Hu T, et al. Identification of an antitumor effect of demethylzeylasteral on human gastric cancer cells[J]. Oncology Letters. 21(1): 1-1.

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