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Deferitazole

CAS号

945635-15-4

分子式

C18H25NO7S

主要靶点

Others

仅限科研使用

Cat No : CM14573

Print datasheet

Synonyms

SPD602|SPD-602|SPD 602|去铁他唑|FBS-0701|FBS 0701|FBS0701|Deferitazole

验证数据展示

  • CAS No.: 945635-15-4

    Deferitazole
    CAS#: 945635-15-4

产品信息

CAS号 945635-15-4
分子式 C18H25NO7S
主要靶点 Others
主要通路 其他
分子量 399.46
纯度 98.26%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 SPD602|SPD-602|SPD 602|去铁他唑|FBS-0701|FBS 0701|FBS0701|Deferitazole

体外活性

Deferitazole (FBS0701) 对铁(III)具有高亲和力和选择性，其表现为 logβ2 = 33.39 ± 0.03 及 pFe(3+) 值为 22.3。在生物条件下，铁(III)复合物存在两种平衡的异构体形式。Deferitazole 也能高亲和地结合三价金属Al(III)和La(III)，其 logβ2 值分别为 26.68 和 21.55。与二价阳离子相比，Deferitazole 的亲和力略低，但对Cu(II)的例外，其 logβ2 值为 25.5；Deferitazole 能够从柠檬酸和白蛋白等动态来源中清除铁，其效率与其他治疗性铁螯合剂，包括 deferasirox、deferiprone 和 desferrioxamine 相当。Fe(III)(Deferitazole)2 在生理条件下稳定且不进行氧化还原循环。Deferitazole 对铁(III)的高亲和力使其不大可能导致铁的重新分布，因此显示出作为治疗性铁(III)螯合剂的巨大潜力。

溶解度

DMSO:50 mg/mL (125.17 mM)

参考文献

1.Hider RC, et al. Deferitazole, a new orally active iron chelator. Dalton Trans. 2015 Mar 21;44(11):5197-204.
2.Ferrer P, et al. Antimalarial iron chelator FBS0701 blocks transmission by Plasmodium falciparum gametocyte activation inhibition. Antimicrob Agents Chemother. 2015 Mar;59(3):1418-26.
3.Gumienna-Kontecka E, et al. Iron chelating strategies in systemic metal overload, neurodegeneration and cancer. Curr Med Chem. 2014;21(33):3741-67.
4.Ferrer P, et al. Antimalarial iron chelator, FBS0701, shows asexual and gametocyte Plasmodium falciparum activity and single oral dose cure in a murine malaria model. PLoS One. 2012;7(5):e37171.

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