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Deferiprone

Deferiprone (Deferidone) 是口服活性铁螯合剂，可研究地中海贫血中的输血性铁过载。

CAS号

30652-11-0

分子式

C7H9NO2

主要靶点

Others|HCV Protease|Ferroptosis|UGT

仅限科研使用

Cat No : CM01948

Print datasheet

Synonyms

CP20|Deferidone|去铁酮

验证数据展示

  • CAS No.: 30652-11-0

    Deferiprone
    CAS#: 30652-11-0

产品信息

Deferiprone is an Iron Chelator. The mechanism of action of deferiprone is as an Iron Chelating Activity.

CAS号 30652-11-0
分子式 C7H9NO2
主要靶点 Others|HCV Protease|Ferroptosis|UGT
主要通路 微生物学|蛋白酶体|凋亡|代谢|其他
分子量 139.15
纯度 99.97%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 CP20|Deferidone|去铁酮

体内活性

1 mM Deferiprone在铁负载的心脏细胞中,导致复合物I-III活性急剧下降。Deferiprone对人肿瘤细胞系HSC-2,HSC-3和HL-60表现出细胞毒性效应,IC50为13.5 μg/mL,9.9 μg/mL以及10.6 μg/mL,HK1对HL-60和HSC-2细胞的细胞毒性在FeCl3存在下降低。100 μg/mL Deferiprone诱导HL-60细胞中核小体间DNA断裂,但是加入FeCl3可以抑制DNA断裂。100 μM Deferiprone能够保护肌细胞免受多柔比星诱导的乳酸脱氢酶释放。在黄嘌呤氧化酶/黄嘌呤超氧化物生成系统中,0.3 mM Deferiprone能够有效抑制放射性铁从铁负载的心脏细胞转移,并保护或恢复线粒体呼吸酶活性。0.5 mM Deferiprone以时间剂量依赖的方式增加RBC膜游离铁的清除。3 mM Deferiprone 也能够大大减少黄嘌呤氧化酶/黄嘌呤超氧化物产生系统中铁（III） - 阿霉素复合物的羟自由基产生。

体外活性

100 mg/kg Deferiprone使家兔的平均基底动脉横截面积减少24％.100 mg/kg Deferiprone联合蛛网膜下腔出血（SAH）显示兔子内部弹性层的波纹量可变

溶解度

H2O:8.33 mg/mL (59.86 mM),Sonification is recommended.,DMSO:7.14 mg/mL (51.31 mM),Sonification is recommended.

参考文献

1.Barnabé N, et al. Free Radic Biol Med, 2002, 33(2), 266-275.
2.Shalev O, et al. Blood, 1995, 86(5), 22008-22013.
3.Link G, et al. J Lab Clin Med, 1999, 133(2), 179-188.
4.Yasumoto E, et al. Anticancer Res, 2004, 24(2B), 755-762.
5.Arthur AS, et al. Neurosurgery, 1997, 41(6), 1385-1391.
6.Deng F, Xu G, Cheng Z, et al. Hepatitis B Surface Antigen Suppresses the Activation of Nuclear Factor Kappa B Pathway via Interaction With the TAK1-TAB2 Complex[J]. Frontiers in Immunology. 2021, 12: 233.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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C1   V1   C2   V2