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DMPO

DMPO (5,5-Dimethyl-1-pyrroline N-oxide) 是一种细胞渗透性亲水自旋诱捕剂，可用于超氧化物检测。

CAS号

3317-61-1

分子式

C6H11NO

主要靶点

Others

仅限科研使用

Cat No : CM16873

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Synonyms

5,5-Dimethyl-1-pyrroline N-oxide|5,5-二甲基-1-吡咯啉-N-氧化物

验证数据展示

  • CAS No.: 3317-61-1

    DMPO
    CAS#: 3317-61-1

产品信息

DMPO is a kind of water-soluble nitric oxide spin trap, which allows the measurement of oxygen-centered free radicals in biological systems at room temperature using electron spin resonance. It has a high reaction rate constant for superoxide and hydroxyl radicals and distinguishes simultaneously among a variety of important biologically generated free radicals.

CAS号 3317-61-1
分子式 C6H11NO
主要靶点 Others
主要通路 其他
分子量 113.16
纯度 99.39%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 5,5-Dimethyl-1-pyrroline N-oxide|5,5-二甲基-1-吡咯啉-N-氧化物

体内活性

When DMPO perfused the heart at 100 μm/L, it attenuated the development of reperfusion arrhythmias during the first 10 min of reperfusion and improved the functional recovery of the heart during reperfusion. Without treatment, 55% of hearts showed irreversible ventricular fibrillation, and this was completely prevented by DMPO, due to its function of traping·O2? and ·OH radicals [2].

体外活性

In vitro, It was demonstrated in red blood cells and in hamster V79 cells that the DMPO spin adducts of ·O2? and ·OH are metabolized very rapidly so that even if formed, they may not be detected in many experiments with cells [1].

溶解度

DMSO:12mg/mL (106.04 mM)

参考文献

1.Samuni A, Samuni A, Swartz HM. The cellular-induced decay of DMPO spin adducts of .OH and .O2. Free Radic Biol Med. 1989;6(2):179-83.
2.Tosaki A1, Blasig IE, Pali T, et al. Heart protection and radical trapping by DMPO during reperfusion in isolated working rat hearts. Free Radic Biol Med. 1990; 8 (4):363-72.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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=
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C1   V1   C2   V2