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DMAT

CAS号

749234-11-5

分子式

C9H7Br4N3

主要靶点

Casein Kinase

仅限科研使用

Cat No : CM08424

Print datasheet

Synonyms

Inhibitor|2-二甲基氨基-4,5,6,7-四溴苯并咪唑|Casein Kinase|CaseinKinase|Casein kinase II Inhibitor|CK2 Inhibitor|CK2|DMAT|inhibit

验证数据展示

  • CAS No.: 749234-11-5

    DMAT
    CAS#: 749234-11-5

产品信息

CAS号 749234-11-5
分子式 C9H7Br4N3
主要靶点 Casein Kinase
主要通路 干细胞|代谢
分子量 476.79
纯度 99.48%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Inhibitor|2-二甲基氨基-4,5,6,7-四溴苯并咪唑|Casein Kinase|CaseinKinase|Casein kinase II Inhibitor|CK2 Inhibitor|CK2|DMAT|inhibit

靶点活性

DYRK2:0.35 μM |CK2:0.13 μM (IC50, Human CK2) |DYRK1A:0.41 μM |HIPK3:0.59 μM |HIPK2:0.37 μM |PKD1:0.18 μM |Pim1:0.148 μM |CDK2:0.64 μM|Pim3:0.097 μM |Pim2:1.6 μM |β-glucuronidase:1.7 μM

体内活性

DMAT 阻断细胞生长并诱导癌细胞死亡，无论是在培养中还是在小鼠异种移植模型中[1][2]。

溶解度

DMSO:50 mg/mL (104.87 mM)

参考文献

1.Lawnicka H , Kowalewicz-Kulbat M , Sicinska P , et al. Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitro[J]. Cell & Tissue Research, 2010, 340(2):371-379.
2.Sass, Gabriele. Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT[J]. International Journal of Oncology, 2011, 39(2).

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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