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DM1-SMe

DM1-SMe (DM1-SSMe) 是美登木素微管的有效抑制剂。 DM1-SMe 的效力是母体药物美登素的 3 至 10 倍，在一组人类肿瘤细胞系中，DM1-SMe 的 IC50 为 0.003 至 0.01 nM。

CAS号

138148-68-2

分子式

C36H50ClN3O10S2

主要靶点

Microtubule Associated

仅限科研使用

Cat No : CM05121

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Synonyms

DM1-SSMe

验证数据展示

  • CAS No.: 138148-68-2

    DM1-SMe
    CAS#: 138148-68-2

产品信息

DM1-SMe is a potent inhibitor of maytansinoid microtubular. DM1-SMe is about 3 to 10-fold more potent than the parent drug Maytansine, with IC50s of 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell lines.

CAS号 138148-68-2
分子式 C36H50ClN3O10S2
主要靶点 Microtubule Associated
主要通路 细胞骨架
分子量 784.38
纯度 ， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 DM1-SSMe

溶解度

DMSO:Soluble,H2O:Insoluble

参考文献

1.Wood AC, et al. Initial testing (Stage 1) of the antibody-maytansinoid conjugate, IMGN901 (Lorvotuzumab mertansine), by the pediatric preclinical testing program. Pediatr Blood Cancer. 2013;60(11):1860-1867.
2.Chari RV. Targeted cancer therapy: conferring specificity to cytotoxic drugs. Acc Chem Res. 2008;41(1):98-107.

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