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DIDS sodium salt

CAS号

67483-13-0

分子式

C16H8N2Na2O6S4

主要靶点

ABC|VDAC

仅限科研使用

Cat No : CM12844

Print datasheet

Synonyms

Voltage-dependent anion channel|VDAC1|VDAC|Inhibitor|MDL101114ZA|ABCA1|4,4'-二异硫氰酸基-2,2'-二苯乙烯磺酸二钠[蛋白质改性试剂]|inhibit|DIDS|DIDS sodium|DIDS sodium salt

验证数据展示

  • CAS No.: 67483-13-0

    DIDS sodium salt
    CAS#: 67483-13-0

产品信息

CAS号 67483-13-0
分子式 C16H8N2Na2O6S4
主要靶点 ABC|VDAC
主要通路 离子通道|离子通道
分子量 498.5
纯度 99.34%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Voltage-dependent anion channel|VDAC1|VDAC|Inhibitor|MDL101114ZA|ABCA1|4,4'-二异硫氰酸基-2,2'-二苯乙烯磺酸二钠[蛋白质改性试剂]|inhibit|DIDS|DIDS sodium|DIDS sodium salt

体外活性

DIDS (<400 μM) 对细胞活性无明显毒剧效应。以100及200 μM浓度预处理DIDS能有效预防ALA-SDT引起的细胞死亡，而50 μM剂量则无抑制效应。100 μM DIDS预处理显著抑制caspase-3和caspase-9的激活[2]。

溶解度

DMSO:45 mg/mL (90.27 mM)

参考文献

1.Tsou CY, et al. Activation of soluble guanylyl cyclase prevents foam cell formation and atherosclerosis. Acta Physiol (Oxf). 2014 Apr;210(4):799-810.
2.Chen H, et al. Inhibition of VDAC1 prevents Ca2?-mediated oxidative stress and apoptosis induced by 5-aminolevulinic acid mediated sonodynamic therapy in THP-1 macrophages. Apoptosis. 2014 Dec;19(12):1712-26.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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