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D-ERYTHRO-SPHINGOSINE

CAS号

123-78-4

分子式

C18H37NO2

主要靶点

Endogenous Metabolite|Phosphatase|PKC

仅限科研使用

Cat No : CM02024

Print datasheet

Synonyms

D ERYTHRO SPHINGOSINE|DERYTHROSPHINGOSINE|D-ERYTHRO-SPHINGOSINE|Endogenous Metabolite|D-鞘氨醇|inhibit|Human Endogenous Metabolite|erythro-C18-Sphingosine|Erythrosphingosine|EndogenousMetabolite|PKC|PP2A|Phosphatase|Protein kinase C|Inhibitor|trans-4-Sphingenine|Sphingosine (d18:1)|Sphingosine-1-phosphate|Sphinganine|鞘氨醇

验证数据展示

  • CAS No.: 123-78-4

    D-ERYTHRO-SPHINGOSINE
    CAS#: 123-78-4

产品信息

CAS号 123-78-4
分子式 C18H37NO2
主要靶点 Endogenous Metabolite|Phosphatase|PKC
主要通路 表观遗传|细胞骨架|代谢|代谢
分子量 299.49
纯度 98%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 D ERYTHRO SPHINGOSINE|DERYTHROSPHINGOSINE|D-ERYTHRO-SPHINGOSINE|Endogenous Metabolite|D-鞘氨醇|inhibit|Human Endogenous Metabolite|erythro-C18-Sphingosine|Erythrosphingosine|EndogenousMetabolite|PKC|PP2A|Phosphatase|Protein kinase C|Inhibitor|trans-4-Sphingenine|Sphingosine (d18:1)|Sphingosine-1-phosphate|Sphinganine|鞘氨醇

靶点活性

p32:8 μM (EC50)

体外活性

D-erythro-Sphingosine在体外[1]抑制蛋白激酶C的活性。研究表明，D-erythro-Sphingosine能够抑制蛋白激酶C，该酶涉及细胞调控和多种信号转导途径，且在不同哺乳动物细胞中展现出抗肿瘤促进活性[2]。

溶解度

DMSO:250 mg/mL (834.75 mM)

参考文献

1.Khan W A , Dobrowsky R , El T S , et al. Protein kinase C and platelet inhibition by D-erythro-sphingosine: comparison with N,N-dimethylsphingosine and commercial preparation.[J]. Biochemical & Biophysical Research Communications, 1990, 172(2):683-691.
2.Pham V T , Joo J E , Tian Y S , et al. A concise synthesis of a promising protein kinase C inhibitor: D-erythro-sphingosine[J]. Archives of Pharmacal Research (Seoul), 2007, 30(1):22-27.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
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C1   V1   C2   V2