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D-AP5

D-AP5 (D-APV) 是一种选择性和竞争性NMDA 受体拮抗剂，Kd 为 1.4 μM。D-AP5 抑制 NMDA 受体的谷氨酸结合位点。

CAS号

79055-68-8

分子式

C5H12NO5P

主要靶点

NMDAR|iGluR

仅限科研使用

Cat No : CM05294

Print datasheet

Synonyms

D-APV|(R)-(-)-2-氨基-5-膦酰戊酸|D-2-Amino-5-phosphonovaleric acid

验证数据展示

  • CAS No.: 79055-68-8

    D-AP5
    CAS#: 79055-68-8

产品信息

D-AP5 is a NMDA receptor antagonist.

CAS号 79055-68-8
分子式 C5H12NO5P
主要靶点 NMDAR|iGluR
主要通路 离子通道|神经科学
分子量 197.13
纯度 100.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 D-APV|(R)-(-)-2-氨基-5-膦酰戊酸|D-2-Amino-5-phosphonovaleric acid

靶点活性

NMDA:1.4 μM(kd)

体内活性

D-AP5 is an NMDA receptor antagonist. Chronic intraventricular injection of D-AP5 can cause dose-dependent parallel damage to spatial learning and long-term enhancement (LTP) in vivo. When preventing spatial learning, the concentration of D-AP5 in the brain cannot cause any measurable sensorimotor disturbances. Compared with the test, D-AP5 infusion will cause a gradual decrease in swimming speed. D-AP5 causes sensorimotor disturbances in space tasks, but gradually deteriorates due to the inability of animals to learn. Rats treated with D-AP5 showed spatially dependent delay-dependent defects in the delayed matching placement protocol of the water maze.

溶解度

Ethanol:< 1 mg/mL (insoluble),H2O:27.78 mg/mL (140.92 mM),Sonification is recommended.

参考文献

1.Davis S, et al. The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro. J Neurosci. 1992 Jan;12(1):21-34.
2.Morris RG, et al. N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of the NMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learning. Eur J Neurosci. 2013 Mar;37(5):700-17.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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