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D-64131

CAS号

74588-78-6

分子式

C16H13NO2

主要靶点

Microtubule Associated

仅限科研使用

Cat No : CM05120

Print datasheet

Synonyms

tubulin-inhibitory|Tubulin polymerization|phase|Inhibitor|Microtubule/Tubulin|Microtubule Associated|MicrotubuleAssociated|D64131|D-64131|D 64131|cytotoxicity|inhibit|G2/M|carcinoma|astrocytoma|antimitotic|antiproliferative|activity

验证数据展示

  • CAS No.: 74588-78-6

    D-64131
    CAS#: 74588-78-6

产品信息

CAS号 74588-78-6
分子式 C16H13NO2
主要靶点 Microtubule Associated
主要通路 细胞骨架
分子量 251.28
纯度 99.67%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 tubulin-inhibitory|Tubulin polymerization|phase|Inhibitor|Microtubule/Tubulin|Microtubule Associated|MicrotubuleAssociated|D64131|D-64131|D 64131|cytotoxicity|inhibit|G2/M|carcinoma|astrocytoma|antimitotic|antiproliferative|activity

靶点活性

Tubulin polymerization:0.53 μM.

体内活性

D-64131剂量依赖性地抑制牛脑微管蛋白的聚合以及[3H]秋水仙碱与生物素化的αβ-微管蛋白的结合。 在用D-64131处理后,许多Y细胞显示异常的微管结构,例如分裂的有丝分裂纺锤体或多个纺锤体极。 在用D-64131处理的许多细胞中可检测到典型的凋亡细胞的核起泡和异常核结构。

体外活性

在裸鼠中,D-64131被证明对人类无疤痕黑素瘤MEXF 989肿瘤异种移植物具有良好的耐受性和高活性. 治疗期间D-64131处理导致显著的肿瘤生长抑制.

溶解度

DMSO:25.1 mg/mL (99.89 mM)

参考文献

1.Beckers T, et al. Y Res. 2002 Jun 1;62(11):3113-9.

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