Cycloastragenol

Cycloastragenol (Astramembrangenin) 是一种三萜皂苷类化合物,是黄芪主要活性成分的水解产物,具有抗氧化、抗炎、抗衰老、抗凋亡和心血管保护作用。它是端粒酶激活剂,可以延长端粒,还能缓解与年龄相关的骨丢失,改善骨微结构和生物力学特性。

CAS号

78574-94-4

分子式

C30H50O5

主要靶点

Epigenetic Reader Domain|Telomerase

仅限科研使用

Cat No : CM01565

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Synonyms

环黄芪醇|Cyclogalegenol|Astramembrangenin



产品信息

Astramembrangenin (Cycloastragenol) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus. Cycloastragenol (CAG) may have a novel therapeutic role in depression

CAS号 78574-94-4
分子式 C30H50O5
主要靶点 Epigenetic Reader Domain|Telomerase
主要通路 DNA损伤和修复|表观遗传
分子量 490.72
纯度 99.98%, 此纯度可做参考,具体纯度与批次有关系,可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 环黄芪醇|Cyclogalegenol|Astramembrangenin

体内活性

oral administration of Cyclogalegenol for 7 days attenuated depression-like behavior in experimental mice.Cyclogalegenol stimulates telomerase activity in human neonatal keratinocytes and rat neuronal cells, and induces CREB activation followed by tert and bcl2 expression. Furthermore, Cyclogalegenol may have a novel therapeutic role in depression[2].

体外活性

Cyclogalegenol has important anti-inflammatory activity by inhibiting lymphocytes activation, proliferation and cytokines expression, this effect may be related to reduction of overall intracellular Ca2+ overload[1].

溶解度

DMSO:98 mg/mL (199.71 mM)

细胞实验

Mouse lymphocytes were obtained from spleens and subjected to Con A for 24?h. Herein, the cells were treated with different concentrations of Cyclogalegenol. Cell viability was assayed by MTT. Pretreated by Cyclogalegenol?and stimulated?by Con A,?the expression of CD69 and CD25, Th1/Th2/Th17 cytokines, cell cycle, proliferation and intracellular Ca2+ concentration ([Ca2+]i) were analyzed by flow cytometry[1].

动物实验

Mice were administered Cyclogalegenol?100 mg/kg, or water by oral gavage, or imipramine 15 mg/kg , a currently?used tricyclic antidepressant, by intraperitoneal injection for 7 days as well as 45 min before testing.?The forced swim test was performed as described previously , by placing a mouse in a glass cylinder (height: 30 cm, diameter: 15 cm) filled with water to a depth of 12 cm.?Mice were tested in the cylinder for 6 min. The water was changed before testing another animal.?All test sessions were recorded.?Depression-like behavior was determined by observing the immobility of the mouse, where immobility is defined as when a mouse floats passively in the water with minimal movement to keep its head above the water.?The total period of immobility during the last 4 min of the test session was determined[2].

参考文献

1.Sun C , Jiang M , Zhang L , et al. Cycloastragenol mediates activation and proliferation suppression in concanavalin A-induced mouse lymphocyte pan-activation model[J]. Immunopharmacology and Immunotoxicology, 2017, 39(3):131-139.
2.Ip F C F , Ng Y P , An H J , et al. Cycloastragenol Is a Potent Telomerase Activator in Neuronal Cells: Implications for Depression Management[J]. Neurosignals, 2014, 22(1):52-63.

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