• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

Clozapine

CAS号

5786-21-0

分子式

C18H19ClN4

主要靶点

AChR|Adrenergic Receptor|Dopamine Receptor

仅限科研使用

Cat No : CM03769

Print datasheet

Synonyms

5-HT Receptor|5-hydroxytryptamine Receptor|Adrenergic Receptor|AdrenergicReceptor|antipsychotic|Beta Receptor|Clozapine|D2|Dopamine Receptor|DopamineReceptor|HeLa|HF1854|HF-1854|HF 1854|α2-adrenoceptor|Serotonin Receptor|schizophrenia|氯氮平|psychosis|inhibit|Inhibitor|mAChR|M1 mAChR|LX 100-129|Muscarinic acetylcholine receptor

验证数据展示

  • CAS No.: 5786-21-0

    Clozapine
    CAS#: 5786-21-0

产品信息

CAS号 5786-21-0
分子式 C18H19ClN4
主要靶点 AChR|Adrenergic Receptor|Dopamine Receptor
主要通路 G 蛋白偶联受体|神经科学|神经科学|神经科学|G 蛋白偶联受体
分子量 326.82
纯度 99.93%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 5-HT Receptor|5-hydroxytryptamine Receptor|Adrenergic Receptor|AdrenergicReceptor|antipsychotic|Beta Receptor|Clozapine|D2|Dopamine Receptor|DopamineReceptor|HeLa|HF1854|HF-1854|HF 1854|α2-adrenoceptor|Serotonin Receptor|schizophrenia|氯氮平|psychosis|inhibit|Inhibitor|mAChR|M1 mAChR|LX 100-129|Muscarinic acetylcholine receptor

靶点活性

M1 receptor:9.5 nM(ki)

体内活性

Clozapine以浓度依赖性方式明显促进NMDA诱发的反应（EC50：14 nM）。Clozapine产生兴奋性突触后电位,被谷氨酸受体拮抗剂阻断,这表明这些兴奋性突触后电位是增加的兴奋性氨基酸的释放的结果。Clozapine是毒蕈碱M4受体的完全激动剂,EC50=11 nM,对forskolin刺激的cAMP累积产生抑制作用。Clozapine对其它4种毒蕈碱受体亚型的激动剂诱导的反应有强效拮抗作用。

体外活性

Clozapine减少独立于前脉冲抑制的大鼠阿朴吗啡治疗.Clozapine显示出'倒U'形的剂量-反应曲线,扭转阿朴吗啡引起的损耗前脉冲抑制.

溶解度

2eq.HCl:16.3 mg/mL (50 mM));DMSO:70 mg/mL (214.19 mM)

参考文献

1.Robertson GS, et al. Neuroscience, 1992, 46(2), 315-328.
2.Nguyen TV, et al. Proc Natl Acad Sci U S A, 1992, 89(10), 4270-4274.
3.Brunello N, et al. Neuropsychopharmacology, 1995, 13(3), 177-213.
4.Arvanov VL, et al. J Pharmacol Exp Ther, 1997, 283(1), 226-234.
5.Zorn SH, et al. Eur J Pharmacol, 1994, 269(3), R1-2.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2