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Cholesteryl Hemisuccinate

CAS号

1510-21-0

分子式

C31H50O4

主要靶点

Topoisomerase|Apoptosis|DNA/RNA Synthesis

仅限科研使用

Cat No : CM11607

Print datasheet

Synonyms

Cholesterol hydrogen succinate|Cholesterol hydrogen Succinate|Cholesteryl|Cholesteryl Hemisuccinate|Apoptosis|DNA Synthesis|DNA polymerase|DNASynthesis|RNASynthesis|RNA Synthesis|胆甾醇半琥珀酸酯|Topo

验证数据展示

  • CAS No.: 1510-21-0

    Cholesteryl Hemisuccinate
    CAS#: 1510-21-0

产品信息

CAS号 1510-21-0
分子式 C31H50O4
主要靶点 Topoisomerase|Apoptosis|DNA/RNA Synthesis
主要通路 细胞周期|DNA 损伤和修复|DNA 损伤和修复|凋亡
分子量 486.73
纯度 99.61%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 store at low temperature | Shipping with blue ice.
别名 Cholesterol hydrogen succinate|Cholesterol hydrogen Succinate|Cholesteryl|Cholesteryl Hemisuccinate|Apoptosis|DNA Synthesis|DNA polymerase|DNASynthesis|RNASynthesis|RNA Synthesis|胆甾醇半琥珀酸酯|Topo

体内活性

Cholesteryl Hemisuccinate（100 mg/kg；ip；AAP前单次给药）在ICR小鼠（CD-1）中消除了AAP引起的凋亡和坏死，用于组织学和生化诊断。[1]

体外活性

Cholesteryl Hemisuccinate (0-1000 μM) 抑制了MCF-7和MCF-10A细胞的生长。[3]

溶解度

Ethanol:22.5 mg/mL (46.2 mM )

参考文献

1.Ray SD, et al. Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment. J Pharmacol Exp Ther. 1996 ; 279(3):1470-1483.
2.Varshosaz J, et al. Folated synperonic-cholesteryl hemisuccinate polymeric micelles for the targeted delivery of docetaxel in melanoma. Biomed Res Int. 2015 ; 2015:746093.
3.Djuric Z, et al. Growth inhibition of MCF-7 and MCF-10A human breast cells by alpha-tocopheryl hemisuccinate, cholesteryl hemisuccinate and their ether analogs. Cancer Lett. 1997 ; 111(1-2):133-139.
4.Pajor L, et al. Cholesteryl hemisuccinate's inductive effect on membrane rigidization regarding both, its remodelling of the cells' surface receptor pattern and its decreasing the natural killer susceptibility of K-562 cells. Acta Biol Hung. 1991 ; 42(4):371-383.
5.Yamamoto Y, et al. Relationship between Thylakoid Membrane Fluidity and the Functioning of Pea Chloroplasts : EFFECT OF CHOLESTERYL HEMISUCCINATE. Plant Physiol. 1981 ; 67(6):1069-1072.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
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C1   V1   C2   V2