Chelidamic acid

CAS号

138-60-3

分子式

C7H5NO5

主要靶点

GluR

仅限科研使用

Cat No : CM01799

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Synonyms

Chelidamic acid|4-氧代-1,4-二氢-2,6-吡啶二甲酸|Glutamate Transporters|inhibit|白屈氨酸|Inhibitor



产品信息

CAS号 138-60-3
分子式 C7H5NO5
主要靶点 GluR
主要通路 神经科学
分子量 183.12
纯度 ≥95%, 此纯度可做参考,具体纯度与批次有关系,可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Chelidamic acid|4-氧代-1,4-二氢-2,6-吡啶二甲酸|Glutamate Transporters|inhibit|白屈氨酸|Inhibitor

靶点活性

Glutamate decarboxylase (GAD):33 μM (Ki)

体外活性

Chelidamic acid 抑制了谷氨酸依赖的脱辅酶形成。Chelidamic acid 本身不促进脱辅酶的形成,也不与游离的吡哆醛磷酸反应。Chelidamic acid 是谷氨酸脱羧酶的抑制剂,其Ki值为33 μM[1]。

溶解度

DMSO:60 mg/mL (327.65 mM)

参考文献

1.Porter T G , Martin D L . Chelidonic acid and other conformationally restricted substrate analogues as inhibitors of rat brain glutamate decarboxylase[J]. Biochemical Pharmacology, 1986, 34(23):4145-4150.
2.Espinet P , García-Orodea, Esther, Miguel, Jesús A. Mesogenic Palladium Complexes with Pincer Ligands Derived from Dipicolinic Acid\r, ?[J]. Inorganic Chemistry, 2000, 39(16):3645-3651.

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