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Chelidamic acid

Chelidamic acid 是一种有效的谷氨酸脱羧酶抑制剂(Ki:33 μM)，也是含有吡喃骨架的杂环有机酸，与金属离子有良好的配位能力。

CAS号

138-60-3

分子式

C7H5NO5

主要靶点

GluR

仅限科研使用

Cat No : CM01799

Print datasheet

Synonyms

4-氧代-1,4-二氢-2,6-吡啶二甲酸|白屈氨酸

验证数据展示

  • CAS No.: 138-60-3

    Chelidamic acid
    CAS#: 138-60-3

产品信息

Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid is inhibitors of glutamate decarboxylase, with a Ki of 33 μM.

CAS号 138-60-3
分子式 C7H5NO5
主要靶点 GluR
主要通路 神经科学
分子量 183.12
纯度 98.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 4-氧代-1,4-二氢-2,6-吡啶二甲酸|白屈氨酸

靶点活性

Glutamate decarboxylase:33 μM (Ki)

体外活性

Chelidonic acid inhibited the glutamate-dependent formation of apoenzyme. Chelidonic acid itself did not promote formation of apoenzyme and did not react with free pyridoxal-P.Chelidamic acid is inhibitors of glutamate decarboxylase, with a Ki of 33 μM[1].

溶解度

DMSO:36 mg/mL (196.59 mM)

参考文献

1.Porter T G , Martin D L . Chelidonic acid and other conformationally restricted substrate analogues as inhibitors of rat brain glutamate decarboxylase[J]. Biochemical Pharmacology, 1986, 34(23):4145-4150.
2.Espinet P , García-Orodea, Esther, Miguel, Jesús A. Mesogenic Palladium Complexes with Pincer Ligands Derived from Dipicolinic Acid\r, ?[J]. Inorganic Chemistry, 2000, 39(16):3645-3651.

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