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Cefaclor

Cefaclor is a cephalosporin antibiotic, used to treat certain bacterial infections with elimination half-life‎ of 0.6 to 0.9 hours.

CAS号

53994-73-3

分子式

C15H14ClN3O4S

主要靶点

Antibacterial

仅限科研使用

Cat No : CM00141

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Synonyms

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  • CAS No.: 53994-73-3

    Cefaclor
    CAS#: 53994-73-3

  • Cefaclor<br/>CAS#: 53994-73-3

    Cefaclor
    CAS#: 53994-73-3

产品信息

Cefaclor is a well-absorbed oral cephalosporin antibiotic. Peak concentrations in serum are attained within 30 - 60 minutes. Cefaclor is not metabolized to a significant degree, but it degrades chemically in the body with an approximate half-life of 2 hours[3]. Cefaclor is active against a wide range of commonly encountered bacterial pathogens, acting by inhibiting cell wall synthesis. Its in vitro activity compares favourably with other beta-lactam antibiotics. Cefaclor has been widely used in infections of the respiratory tract (including otitis media), urinary tract and soft tissues[4]. Multiple clinical trials have shown that extended-release cefaclor in 375-mg and 500-mg doses BID demonstrates tolerability and efficacy comparable to those of immediate-release cefaclor 250 mg TID[5]. Moreover, only collagen scaffolds loaded with 100 μg/ml Cefaclor exhibited adequate antibacterial properties against both 106 and 108 colony-forming units per ml of both Escherichia coli and Staphylococcus epidermidis[6]. Patients with cefaclor anaphylaxis exhibit high serum IgE levels. A cut-off value of 0.11 kU/L of sIgE (serum-specific IgE) to cefaclor is proper for identifying patients with cefaclor allergy, and 0.44 kU/L may be useful to detect anaphylaxis[7].

CAS号 53994-73-3
分子式 C15H14ClN3O4S
主要靶点 Antibacterial
主要通路 Anti-infection
分子量 367.8074
MDL NO MFCD00151471
Pubchem ID 51039
纯度 98%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件
粉末 -20°C 3年
液体 -80°C 1年
运输条件 Shipped in cold pack
别名

溶解度

DMSOinsoluble
Waterinsoluble
Ethanolinsoluble

参考文献

1King BA, Geelhoed GC. Adverse skin and joint reactions associated with oral antibiotics in children: the role of cefaclor in serum sickness-like reactions. J Paediatr Child Health. 2003 Dec;39(9):677-81.
2Ito S, Blajchman A, et al. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9.
3Sourgens H, Derendorf H, Schifferer H. Pharmacokinetic profile of cefaclor. Int J Clin Pharmacol Ther. 1997;35(9):374‐380
4Brumfitt W, Hamilton-Miller JM. Cefaclor into the millennium. J Chemother. 1999;11(3):163‐178
5Meyers BR. Cefaclor revisited. Clin Ther. 2000;22(2):154‐166
6Tsekoura EK, Helling AL, Wall JG, Bayon Y, Zeugolis DI. Battling bacterial infection with hexamethylene diisocyanate cross-linked and Cefaclor-loaded collagen scaffolds. Biomed Mater. 2017;12(3):035013. Published 2017 Jun 19
7Nam YH, Lee SH, Rhyou HI, et al. Proper Cut-off Levels of Serum Specific IgE to Cefaclor for Patients with Cefaclor Allergy. Yonsei Med J. 2018;59(8):968‐974

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