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Cardiogenol C hydrochloride

CAS号

1049741-55-0

分子式

C13H17ClN4O2

主要靶点

Wnt/beta-catenin

仅限科研使用

Cat No : CM17109

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Synonyms

Cardiogenol C HCl|Cardiomyogenic|bcatenin|betacatenin|beta-catenin|esc|MHC|pyrimidine|plasticity|transplantation,?progenitor|β-catenin|βcatenin|Wnt|Wnt/β-catenin|Wnt/betacatenin|Wnt/b-catenin|stem

验证数据展示

  • CAS No.: 1049741-55-0

    Cardiogenol C hydrochloride
    CAS#: 1049741-55-0

产品信息

CAS号 1049741-55-0
分子式 C13H17ClN4O2
主要靶点 Wnt/beta-catenin
主要通路 干细胞|细胞骨架
分子量 296.75
纯度 100%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Cardiogenol C HCl|Cardiomyogenic|bcatenin|betacatenin|beta-catenin|esc|MHC|pyrimidine|plasticity|transplantation,?progenitor|β-catenin|βcatenin|Wnt|Wnt/β-catenin|Wnt/betacatenin|Wnt/b-catenin|stem

靶点活性

Differentiation of ESCs into cardiomyocytes:100 nM (EC50)

体外活性

Cardiogenol C 可以诱导 HBPCs 表达转录因子 GATA4、Nkx2.5 和 Tbx5，这些是预心肌细胞早期的特异性标志[1]。

溶解度

DMSO:70 mg/mL (235.89 mM);H2O:2 mg/mL (6.74 mM)

细胞实验

Used GMEM plus 5 μM Cardiogenol C and 7.5% ESQ-FBS.?The cultures were harvested at different day-intervals after induction for immunohistochemistry, semi-quantitative RT-PCR analysis, western blot analysis and comparative proteomic[1].

参考文献

1.Yau, Winifred WY, Tang, Mei-Kuen, Chen, Elve,et al. Cardiogenol C can induce Mouse Hair Bulge Progenitor Cells to Transdifferentiate into Cardiomyocyte-like Cells[J]. Proteome Science, 9(1):3.
2.Koley M , Mike A K , Heher P , et al. VUT-MK142 : a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes[J]. MedChemComm, 2013, 4(8):1189.

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