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Candesartan

CAS号

139481-59-7

分子式

C24H20N6O3

主要靶点

RAAS

仅限科研使用

Cat No : CM00672

Print datasheet

Synonyms

angiotensin II AT1-Receptor|Angiotensin Receptor|antihypertensive|Candesartan|AT1 receptor|CV11974|CV-11974|CV 11974|inhibit|hypertension|hronic heart failure (CHF)|Traumatic brain injury (TBI)|坎地沙坦|Inhibitor|oral|PPAR-γ

验证数据展示

  • CAS No.: 139481-59-7

    Candesartan
    CAS#: 139481-59-7

产品信息

CAS号 139481-59-7
分子式 C24H20N6O3
主要靶点 RAAS
主要通路 内分泌与激素
分子量 440.47
纯度 99.55%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 angiotensin II AT1-Receptor|Angiotensin Receptor|antihypertensive|Candesartan|AT1 receptor|CV11974|CV-11974|CV 11974|inhibit|hypertension|hronic heart failure (CHF)|Traumatic brain injury (TBI)|坎地沙坦|Inhibitor|oral|PPAR-γ

靶点活性

AT1 receptor:0.26 nM

体内活性

在CHO-AT1细胞中,Candesartan 能够高选择性地与血管紧张素II AT1 受体结合。Candesartan（0.1 nM）能够降低对于血管紧张素II的最大收缩反应。在 KU-19-19细胞中,加入Candesartan,能够上调VEGF和和白细胞介素-8的表达,同时不影响细胞增殖。

体外活性

在处理携带KU-19-19移植瘤的小鼠中,Candesartan（10 mg/kg）能够降低微血管密度和VEGF的表达,抑制肿瘤细胞生长.在WKY大鼠中,Candesartan（0.5 mg/kg ）能够降低血压,抑制AT1在穹窿下器,下丘脑室旁核,孤束核,和极后区的结合.在成年自发性高血压大鼠中,Candesartan（0.3 mg/kg）能够减少梗死区域,减少在缺血周边区域和皮层下严重缺血性病变区域,减低脑部血流量的减少.

溶解度

DMSO:4.5 mg/mL (10.22 mM);Ethanol:0.4 mg/mL (10 mM))

细胞实验

KU-19-19 cells are seeded at a cell density of 2 × 104 per well in 96-well plates and allowed to grow overnight. Then the cells are treated with various concentrations of Candesartan for various periods of time. Cell viability is determined by the Alamar Blue assay to examine the cytotoxicity and antiproliferative effect of candesartan. The absorbance value of each well is determined in a microplate reade(Only for Reference)

参考文献

1.Fierens F, et al. Eur J Pharmacol, 1999, 367(2-3), 413-422.
2.Kosugi M, et al. Clin Cancer Res, 2006, 12(9), 2888-2893.
3.Ojima M, et al. Eur J Pharmacol, 1997, 319(1), 137-146.
4.Nishimura Y, et al. Brain Res, 2000, 871(1), 29-38.
5.Ito T, et al. Stroke, 2002, 33(9), 2297-2303.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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