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Folinic acid calcium

Folinic acid calcium (Leucovorin Calcium) 是叶酸的活性代谢物，是一种解毒剂，通常与甲氨蝶呤 (MTX) 联用，以降低 MTX 诱导的毒性。

CAS号

1492-18-8

分子式

C20H21CaN7O7

主要靶点

Endogenous Metabolite|Antifolate|DNA/RNA Synthesis

仅限科研使用

Cat No : CM00681

Print datasheet

Synonyms

Folinic acid calcium salt|Wellcovorin|亚叶酸钙|Calcium folinate|Leucovorin Calcium

验证数据展示

  • CAS No.: 1492-18-8

    Folinic acid calcium
    CAS#: 1492-18-8

产品信息

Folinic acid calcium (Leucovorin Calcium) is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists.

CAS号 1492-18-8
分子式 C20H21CaN7O7
主要靶点 Endogenous Metabolite|Antifolate|DNA/RNA Synthesis
主要通路 DNA损伤和修复|细胞周期|代谢
分子量 511.51
纯度 99.30%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 Folinic acid calcium salt|Wellcovorin|亚叶酸钙|Calcium folinate|Leucovorin Calcium

靶点活性

zmSHMT:70 μM|zcSHMT:30 μM

溶解度

DMSO:Insoluble,H2O:10 mM

参考文献

1.Aschele C, et al. Ann Oncol. 2002 Dec; 13(12):1882-92.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2