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CYM50358

CAS号

1314212-39-9

分子式

C20H18Cl2N2O2

主要靶点

LPL Receptor

仅限科研使用

Cat No : CM04984

Print datasheet

Synonyms

CYM50358|CYM-50358|CYM 50358|inhibit|S1PR4|Lysophospholipid Receptor|LPL Receptor|LPLReceptor|Inhibitor

验证数据展示

  • CAS No.: 1314212-39-9

    CYM50358
    CAS#: 1314212-39-9

产品信息

CAS号 1314212-39-9
分子式 C20H18Cl2N2O2
主要靶点 LPL Receptor
主要通路 G 蛋白偶联受体
分子量 389.28
纯度 99.76%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 CYM50358|CYM-50358|CYM 50358|inhibit|S1PR4|Lysophospholipid Receptor|LPL Receptor|LPLReceptor|Inhibitor

靶点活性

S1PR4:25 nM

体外活性

N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 对S1PR1的抑制作用较弱(IC50=6.4μM)[1]。N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 (10μM)对胶原诱导的HSP27磷酸化无影响，显著逆转了S1P对胶原诱导的HSP27磷酸化的抑制效果[2]。

溶解度

DMSO:125 mg/mL (321.11 mM)

参考文献

1.Guerrero M,et,al.Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists.Bioorg Med Chem Lett. 2011 Jun 15;21(12):3632-6.
2.Onuma T, et, al. Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor.Thromb Res. 2017 Aug;156:91-100.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2