• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

CUR61414

CAS号

334998-36-6

分子式

C31H42N4O5

主要靶点

Hedgehog/Smoothened

仅限科研使用

Cat No : CM13885

Print datasheet

Synonyms

Hedgehog|Hedgehog inhibitor|CUR 61414|CUR61414|CUR-61414|Smoothened

验证数据展示

  • CAS No.: 334998-36-6

    CUR61414
    CAS#: 334998-36-6

产品信息

CAS号 334998-36-6
分子式 C31H42N4O5
主要靶点 Hedgehog/Smoothened
主要通路 干细胞|G 蛋白偶联受体
分子量 550.69
纯度 98.00%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
别名 Hedgehog|Hedgehog inhibitor|CUR 61414|CUR61414|CUR-61414|Smoothened

体内活性

CUR61414能够使暴露于紫外线照射的小鼠身上的病变退化，并在它们的皮肤中产生许多微观的BCC样基底样病变[1]。

体外活性

CUR61414可以阻止BCC样病变中基底细胞的增殖，并诱导细胞凋亡以及病变的完全消退，同时不影响周围的非肿瘤细胞[1]。

溶解度

DMSO:90.9 mg/mL (165.1 mM)

参考文献

1.Williams JA, et al. Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4616-21. Epub 2003 Apr 4.
2.Frank-Kamenetsky M, et al. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.J Biol. 2002 Nov 6;1(2):10.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
=
×
×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
×
=
×
C1   V1   C2   V2