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CU-CPT-8m

CU-CPT-8m (TLR8-specific antagonist) 是TLR8特异性拮抗剂，IC50值为 67 nM。

CAS号

125079-83-6

分子式

C14H12N4O

主要靶点

TLR

仅限科研使用

Cat No : CM06661

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Synonyms

TLR8-specific antagonist

验证数据展示

  • CAS No.: 125079-83-6

    CU-CPT-8m
    CAS#: 125079-83-6

产品信息

CU-CPT-8m is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)

CAS号 125079-83-6
分子式 C14H12N4O
主要靶点 TLR
主要通路 免疫与炎症
分子量 252.27
纯度 98.97%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Powder: -20°C for 3 years | In solvent: -80°C for 1 year
别名 TLR8-specific antagonist

靶点活性

TLR8:67 nM

体内活性

CU-CPT8m decreases TNF-α and IL-8 levels in synovial cells derived from patients with osteoarthritis and TNF-α levels in PBMCs derived from patients with rheumatoid arthritis.

溶解度

DMSO:30 mg/mL (118.92 mM)

参考文献

1.Zhang S , Hu Z , Tanji H , et al. Small-molecule inhibition of TLR8 through stabilization of its resting state[J]. Nature Chemical Biology, 2017, 14(1):58-64.

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